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. 2024 Jun;61(6):735-743.
doi: 10.1007/s00592-024-02249-6. Epub 2024 Mar 4.

High remnant cholesterol as a risk factor for developing chronic kidney disease in patients with prediabetes and type 2 diabetes: a cross-sectional study of a US population

Wenting Zhu  1 , Qiushi Liu  2   3 , Fang Liu  1 , Chenfeng Jiao  1 , Lihua Zhang  1 , Honglang Xie  4
Affiliations

High remnant cholesterol as a risk factor for developing chronic kidney disease in patients with prediabetes and type 2 diabetes: a cross-sectional study of a US population

Wenting Zhu et al. Acta Diabetol. 2024 Jun.

Erratum in

Abstract

Aims: To examine any potential links between remnant cholesterol (RC) and comorbid chronic kidney disease (CKD) in individuals with prediabetes and type 2 diabetes mellitus (T2DM).

Methods: We used data from 2709 American people aged > 20 years from the National Health and Nutrition Examination Survey (NHANES) during 2011-2018. Subjects were categorized according to whether they had comorbid CKD. Logistic regression models and smoothed curve fitting methods were employed to assess the association of RC with comorbid CKD in patients with prediabetes and T2DM.

Results: The 2709 participants included 1473 patients with T2DM and 1236 with prediabetes [impaired glucose tolerance (IGT) and impaired fasting glucose (IFG)], of whom 744 (27.46%) had comorbid CKD. In multivariate-adjusted analysis, both RC and triglycerides (TG) were significantly associated with an increased risk of comorbid CKD, and a 1 mmol/L elevation of RC increased the risk by 38.1% [OR (95% CI) 1.636 (1.242, 2.156)], which was higher than the risk associated with a 1 mmol/L increase in TG [1.255 (1.106, 1.424)]. Additionally, those in the highest quartile of RC had a 43.6% higher risk of concomitant renal damage than those in the lowest quartile. RC was linearly and positively associated with the incidence of comorbid CKD in this population.

Conclusions: RC is an independent risk factor for comorbid CKD in patients with prediabetes and T2DM. This finding provides a novel insight into the management and early detection of renal disease in patients with impaired glucose metabolism.

Keywords: Chronic kidney disease; NHANES; Prediabetes; Remnant cholesterol; Type 2 diabetes mellitus.

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Conflict of interest statement

The authors have no competing interests to disclose.

Figures

Fig. 1
Fig. 1
Flowchart of study participants
Fig. 2
Fig. 2
Density dose–response relationship between remnant cholesterol and comorbid CKD. Notes The area between two dotted lines is expressed as a 95% CI
Fig. 3
Fig. 3
Odds ratios for the connection between RC and risk of CKD in various subgroups. Notes Theses odds ratios are derived from in logistic regression Model 3
See this image and copyright information in PMC

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