Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May;13(5):1061-1069.
doi: 10.1007/s40123-024-00909-y. Epub 2024 Mar 4.

A Patient-Centered Approach to Vernal Keratoconjunctivitis (VKC): A Podcast

Affiliations

A Patient-Centered Approach to Vernal Keratoconjunctivitis (VKC): A Podcast

Ann Cathrine Larsen et al. Ophthalmol Ther. 2024 May.

Abstract

Vernal keratoconjunctivitis (VKC) is a rare yet severe form of allergic conjunctivitis predominantly affecting children, mainly boys, with a global prevalence and a higher incidence in certain geographical regions. The disease is characterized by seasonal exacerbations. VKC presents with ocular surface inflammation leading to various distressing symptoms such as itching, redness, mucous discharge, and pain. The disease primarily manifests bilaterally, though it may initially appear unilaterally. If left untreated, VKC can result in corneal complications, including shield ulcers and vision impairment, affecting daily activities and psychosocial well-being, especially in children. The diagnosis of VKC involves identifying key clinical findings on the ocular surface such as Tranta dots, giant papillae, or shield ulcers. Management follows a stepwise approach, including anti-allergic eye drops, steroid eye drops, and topical medications like cyclosporine, which may take up to 3 months to show efficacy. Allergic sensitization, often to inhaled allergens like pollen and house dust mites, is associated with VKC in half of the cases. Understanding and managing these allergies through measures such as avoidance, sensitization control, and co-treatment of associated conditions like asthma and rhinoconjunctivitis are essential in VKC management. Atopic keratoconjunctivitis (AKC), a related condition associated with atopic dermatitis and asthma, shares similarities with VKC but typically affects young adults. However, there is an observed spectrum between the two diseases, indicating similar treatment strategies for both. VKC treatment requires a patient-centered approach, involving informed and supported parents, considering economic factors due to costly eye drops, and ensuring accessibility and practicality of treatment, especially in children. A multidisciplinary team collaboration, including ophthalmologists, pediatricians, and dermatologists, optimizes patient care. The rewarding aspect of VKC treatment lies in witnessing children regain their quality of life, overcome vision challenges, and thrive in their daily activities. In conclusion, understanding VKC, its associated allergies, and employing a comprehensive, patient-centered approach are crucial in managing this challenging condition, particularly in children, to enhance their vision and overall well-being.

Keywords: Giant papillae; Pediatric ophthalmology; Shield ulcers; Stepvise therapy; Vernal keratoconjuctivitis.

PubMed Disclaimer

Conflict of interest statement

Author Marie Louise Roed Rasmussen declares to have received speaker fees for lectures from Santen, and to have received advisory board honorarium from Santen. Ann Catherine Larson has no conflicts in interest to declare.

Similar articles

Cited by

References

    1. Rasmussen MLR, Schou MG, Bach-Holm D, et al. Comparative efficacy of medical treatments for vernal keratoconjunctivitis in children and young adults: a systematic review with network meta-analyses. Acta Ophthalmol. 2022 doi: 10.1111/aos.14858. - DOI - PubMed
    1. Leonardi A, Motterle L, Bortolotti M. Allergy and the eye. Clin Exp Immunol. 2008;153(Suppl):17–21. doi: 10.1111/j.1365-2249.2008.03716.x. - DOI - PMC - PubMed
    1. Ghauri AJ, Biswas S, Manzouri B, Barua A, Sharma V, Hoole J, Dahlmann-Noor A. Management of vernal keratoconjunctivitis in children in the United Kingdom: a review of the literature and current best practice across six large United Kingdom centers. J Pediatr Ophthalmol Strabismus. 2023;60:1–17. doi: 10.3928/01913913-20220328-01. - DOI - PubMed
    1. Montan PG, Ekström K, Hedlin G, van Hage-Hamsten M, Hjern A, Herrmann B. Vernal keratoconjunctivitis in a Stockholm ophthalmic centre–epidemiological, functional, and immunologic investigations. Acta Ophthalmol Scand. 1999;77:559–563. doi: 10.1034/j.1600-0420.1999.770516.x. - DOI - PubMed
    1. Bremond-Gignac D, Donadieu J, Leonardi A, et al. Prevalence of vernal keratoconjunctivitis: a rare disease? Br J Ophthalmol. 2008;92:1097–1102. doi: 10.1136/bjo.2007.117812. - DOI - PubMed

LinkOut - more resources