Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

Ziya Isiksacan^{1

2}, Angelo D'Alessandro³, David H McKenna⁴, Shannon N Tessier^{1

2}, Erdem Kucukal⁵, A Aslihan Gokaltun^{1

2

6}, Nishaka William⁷, Rebecca D Sandlin¹, John Bischof^{8

9}, Narla Mohandas¹⁰, Michael P Busch^{11

12}, Caglar Elbuken^{13

14

15}, Umut A Gurkan^{16

17

18}, Mehmet Toner^{1

2}, Jason P Acker^{7

19}, Martin L Yarmush^{1

2

20}, O Berk Usta^{1

2}

Affiliations

¹ Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
² Shriners Children's, Boston, MA 02114.
³ Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045.
⁴ Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455.
⁵ BioChip Labs, Cleveland, OH 44195.
⁶ Department of Chemical Engineering, Hacettepe University, Ankara 06532, Turkey.
⁷ Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R8, Canada.
⁸ Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455.
⁹ Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.
¹⁰ New York Blood Center, New York, NY 10065.
¹¹ Vitalant Research Institute, San Francisco, CA 94105.
¹² Department of Laboratory Medicine, University of California, San Francisco, CA 94105.
¹³ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
¹⁴ Faculty of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Oulu, Oulu 90014, Finland.
¹⁵ Valtion Teknillinen Tutkimuskeskus Technical Research Centre of Finland Ltd., Oulu 90570, Finland.
¹⁶ Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106.
¹⁷ Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
¹⁸ Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.
¹⁹ Innovation and Portfolio Management, Canadian Blood Services, Edmonton, AB T6G 2R8, Canada.
²⁰ Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854.

PMID: 38437566
PMCID: PMC10945785
DOI: 10.1073/pnas.2320521121

Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

Ziya Isiksacan et al. Proc Natl Acad Sci U S A. 2024.

. 2024 Mar 12;121(11):e2320521121.

doi: 10.1073/pnas.2320521121. Epub 2024 Mar 4.

Authors

Affiliations

¹ Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
² Shriners Children's, Boston, MA 02114.
³ Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO 80045.
⁴ Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455.
⁵ BioChip Labs, Cleveland, OH 44195.
⁶ Department of Chemical Engineering, Hacettepe University, Ankara 06532, Turkey.
⁷ Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R8, Canada.
⁸ Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455.
⁹ Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455.
¹⁰ New York Blood Center, New York, NY 10065.
¹¹ Vitalant Research Institute, San Francisco, CA 94105.
¹² Department of Laboratory Medicine, University of California, San Francisco, CA 94105.
¹³ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
¹⁴ Faculty of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Oulu, Oulu 90014, Finland.
¹⁵ Valtion Teknillinen Tutkimuskeskus Technical Research Centre of Finland Ltd., Oulu 90570, Finland.
¹⁶ Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106.
¹⁷ Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
¹⁸ Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.
¹⁹ Innovation and Portfolio Management, Canadian Blood Services, Edmonton, AB T6G 2R8, Canada.
²⁰ Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854.

PMID: 38437566
PMCID: PMC10945785
DOI: 10.1073/pnas.2320521121

No abstract available

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Conflict of interest statement

Competing interests statement:U.A.G. and Case Western Reserve University have financial interests in Hemex Health Inc. E.K., U.A.G., and Case Western Reserve University have financial interests in BioChip Labs Inc. U.A.G. and Case Western Reserve University have financial interests in Xatek Inc. U.A.G. has financial interests in DxNow Inc. Financial interests include licensed intellectual property, stock ownership, research funding, employment, and consulting. Hemex Health Inc. offers point-of-care diagnostics for hemoglobin disorders, anemia, and malaria. BioChip Labs Inc. offers commercial clinical microfluidic biomarker assays for inherited or acquired blood disorders. Xatek Inc. offers point-of-care global assays to evaluate the hemostatic process. DxNow Inc. offers microfluidic and bio-imaging technologies for in vitro fertilization, forensics, and diagnostics. Competing interests of Case Western Reserve University employees are overseen and managed by the Conflict of Interests Committee according to a Conflict-of-Interest Management Plan. The study was conducted prior to E.K. employment at IDEXX Laboratories, and the ideas expressed are not in his capacity as an IDEXX employee. A.D. serves on the Scientific Advisory Board of Hemanext Inc. and Macopharma Inc., and his competing interests are managed by the University of Colorado in accordance with their conflict-of-interest policies. S.N.T. and M.T. serve on the Scientific Advisory Board of Sylvatica Biotech Inc., a company focused on developing high subzero organ preservation technology. Competing interests for all authors affiliated with the Massachusetts General Hospital are managed by the MGH and Mass General Brigham in accordance with their conflict-of-interest policies. The remaining authors declare no competing interests.

References

1. Isiksacan Z., et al. , Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine. Proc. Natl. Acad. Sci. U.S.A. 120, e2115616120 (2023). - PMC - PubMed
1. Kaestner L., et al. , Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion. Proc. Natl. Acad. Sci. U.S.A., e2318762121 (2024). - PubMed
1. Recktenwald S. M., et al. , Erysense, a lab-on-a-chip-based point-of-care device to evaluate red blood cell flow properties with multiple clinical applications. Front. Physiol. 13, 884690 (2022). - PMC - PubMed
1. Doan M., et al. , Objective assessment of stored blood quality by deep learning. Proc. Natl. Acad. Sci. U.S.A. 117, 21381–21390 (2020). - PMC - PubMed
1. Islamzada E., et al. , Deformability based sorting of stored red blood cells reveals donor-dependent aging curves. Lab Chip 20, 226–235 (2020). - PubMed

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Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

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Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

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