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Case Reports
. 2025 Mar 1;19(2):148-151.
doi: 10.1097/ICB.0000000000001555.

THE SPECTRUM OF RELENTLESS PLACOID AND ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY: A MULTIMODAL IMAGING ANALYSIS

Xavier Chan  1 , Johnell Renz Amoroso  2 , Quan V Hoang  1   3 , Jesse J Jung  2   4
Affiliations
Case Reports

THE SPECTRUM OF RELENTLESS PLACOID AND ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY: A MULTIMODAL IMAGING ANALYSIS

Xavier Chan et al. Retin Cases Brief Rep. .

Abstract

Purpose: The objective of this study was to showcase the spectrum between acute posterior multifocal placoid pigment epitheliopathy and relentless placoid utilizing ultra-widefield imaging findings of a case of acute posterior multifocal placoid pigment epitheliopathy progressing to relentless placoid chorioretinitis.

Methods: A 23-year-old White woman presented with worsening vision in both eyes. Clinical examination and multimodal imaging modalities including fundus photographs, fundus autofluorescence, fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography and angiography were utilized to diagnose acute posterior multifocal placoid pigment epitheliopathy and clinically follow the patient.

Results: Clinical examination of the patient initially revealed posterior lesions consistent with acute posterior multifocal placoid pigment epitheliopathy, but subsequent multimodal images including ultra-widefield fluorescein angiography and indocyanine green angiography revealed newer, more peripheral lesions more typical of relentless placoid chorioretinitis.

Conclusion: When compared with standard multimodal imaging, ultra-widefield imaging is an effective tool to delineate nuances between acute posterior multifocal placoid pigment epitheliopathy and relentless placoid chorioretinitis through identification of peripheral lesions, which may be of clinical importance when determining management and therapeutics for patients.

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