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Observational Study
. 2024 Mar 4;14(1):5341.
doi: 10.1038/s41598-024-55499-3.

Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy

Thanakhom Hoontrakul  1 , Charoen Leenanupunth  2 , Mookdarat Siantong  2 , Pokket Sirisreetreerux  3 , Sith Phongkitkarun  4 , Wisoot Kongchareonsombat  2 , Kittinut Kijvikai  2
Affiliations
Observational Study

Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy

Thanakhom Hoontrakul et al. Sci Rep. .

Erratum in

Abstract

To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up.

Keywords: Chronic kidney disease; Donor nephrectomy; Long-term follow-up; Residual renal volume.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
CKD development according to remnant kidney volume (> 50 or < 50%). Remark: the Y axis shows cumulative incidence of CKD development over time.
See this image and copyright information in PMC

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