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Meta-Analysis
. 2024 Mar 4;24(1):220.
doi: 10.1186/s12877-024-04765-0.

Meta-analysis and systematic review of the relationship between sex and the risk or incidence of poststroke aphasia and its types

Ting-Ting Li #  1 , Ping-Ping Zhang #  2 , Ming-Chen Zhang #  1 , Hui Zhang  1 , Hong-Ying Wang  1 , Ying Yuan  1 , Shan-Lin Wu  1 , Xiao-Wen Wang  3 , Zhong-Guang Sun  4
Affiliations
Meta-Analysis

Meta-analysis and systematic review of the relationship between sex and the risk or incidence of poststroke aphasia and its types

Ting-Ting Li et al. BMC Geriatr. .

Abstract

Objective: To analyse and discuss the association of gender differences with the risk and incidence of poststroke aphasia (PSA) and its types, and to provide evidence-based guidance for the prevention and treatment of poststroke aphasia in clinical practice.

Data sources: Embase, PubMed, Cochrane Library and Web of Science were searched from January 1, 2002, to December 1, 2023.

Study selection: Including the total number of strokes, aphasia, the number of different sexes or the number of PSA corresponding to different sex.

Data extraction: Studies with missing data, aphasia caused by nonstroke and noncompliance with the requirements of literature types were excluded.

Data synthesis: 36 papers were included, from 19 countries. The analysis of 168,259 patients with stroke and 31,058 patients with PSA showed that the risk of PSA was 1.23 times higher in female than in male (OR = 1.23, 95% CI = 1.19-1.29, P < 0.001), with a prevalence of PSA of 31% in men and 36% in women, and an overall prevalence of 34% (P < 0.001). Analysis of the risk of the different types of aphasia in 1,048 patients with PSA showed a high risk in females for global, broca and Wenicke aphasia, and a high risk in males for anomic, conductive and transcortical aphasia, which was not statistically significant by meta-analysis. The incidence of global aphasia (males vs. females, 29% vs. 32%) and broca aphasia (17% vs 19%) were higher in females, and anomic aphasia (19% vs 14%) was higher in males, which was statistically significant (P < 0.05).

Conclusions: There are gender differences in the incidence and types of PSA. The risk of PSA in female is higher than that in male.

Keywords: Poststroke aphasia; Sex; aphasia type; incidence rate; stroke.

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Conflict of interest statement

The authors declare no competing interests.

Figures

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Flow diagram
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Sex and the risk of poststroke aphasia
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Incidence of poststroke aphasia
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Incidence of poststroke aphasia in male
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Incidence of poststroke aphasia in female
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Incidence of global aphasia
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Incidence of broca aphasia
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Incidence of anomic aphasia
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Incidence of wernicke aphasia
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Incidence of transcortical mixed aphasia
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Incidence of conductive aphasia
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Incidence of transcortical sensory aphasia
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Incidence of transcortical mortor aphasia
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Incidence of other type of aphasia
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