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Randomized Controlled Trial
. 2024 Mar 5;15(1):62.
doi: 10.1186/s13287-024-03675-7.

Evaluation of the efficacy of mesenchymal stem cells derived conditioned medium in the treatment of striae distensae: a double blind randomized clinical trial

Elham Behrangi #  1   2 , Masoomeh Feizollahi #  1   2 , Sona Zare  2   3   4   5 , Azadeh Goodarzi  1   2 , Mohammad Reza Ghasemi  1   2 , Afsaneh Sadeghzadeh-Bazargan  1   2 , Abbas Dehghani  1   2 , Maryam Nouri  2 , Roya Zeinali  1   2 , Masoomeh Roohaninasab  6   7 , Mohammad Ali Nilforoushzadeh  8   9
Affiliations
Randomized Controlled Trial

Evaluation of the efficacy of mesenchymal stem cells derived conditioned medium in the treatment of striae distensae: a double blind randomized clinical trial

Elham Behrangi et al. Stem Cell Res Ther. .

Abstract

Background: Striae distensae is a disfiguring atrophic skin condition that impairs the body's aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchymal stem cells are considered a rich source for scar treatment. Skin needling is among the most efficient and safe aesthetic and therapeutic devices. This study aimed to evaluate the efficacy of the combination of needling and intradermal injection of mesenchymal stem cells compared to skin needling alone for treating striae distensae.

Method: This study was a randomized, double-blind clinical trial involving 10 women aged 18-60. Each striae lesion was divided into two parts, with one side receiving needling and intradermal injection of conditioned medium, while the other side received needling and intradermal injection of normal saline. This treatment was administered in three sessions with three-week intervals. Patients were evaluated before the first intervention and three months after the final session. Three months after the completion of the intervention, patients' lesions were evaluated using biometric criteria, physician evaluation, and patient self-assessment.

Results: The results demonstrated a significant improvement in dermal and complete thickness and skin density in patients treated with microneedling. All skin ultrasound parameters improved significantly in patients receiving the combination of needling and conditioned medium. When comparing the two groups, significantly higher physician and patient satisfaction was observed in the combination group. However, the comparison of biometric indices improvement wasn't significant between these groups.

Conclusion: The combination of human mesenchymal stem cells with microneedling could be considered a novel effective option for stretch marks.

Keywords: Clinical trial; Conditioned medium; Efficacy; Microneedling; Striae; Striae distensae.

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Conflict of interest statement

All authors declare no conflict of interest for this project.

Figures

Fig. 1
Fig. 1
Needling and intradermal injection of conditioned medium, left: before, right: after
Fig. 2
Fig. 2
Needling and intradermal injection of normal saline, left: before, right: after
See this image and copyright information in PMC

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