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. 2024 Feb 2:14:1290731.
doi: 10.3389/fendo.2023.1290731. eCollection 2023.

Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study

Yunfeng Yu #  1 , Xinyu Yang #  2 , Gang Hu  2 , Keke Tong  3 , Yuman Yin  2 , Rong Yu  1
Affiliations

Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study

Yunfeng Yu et al. Front Endocrinol (Lausanne). .

Abstract

Objective: The effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).

Methods: Forty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank. SNPs for uric acid were obtained from BioBank Japan, SNPs for gout were obtained from UK Biobank, and SNPs for gout due to impairment of renal function and idiopathic gout were derived from FinnGen. The causal relationship of exposure-outcome was tested using inverse variance weighted, MR-Egger and weighted median. MR-Egger intercept was employed to assess horizontal pleiotropy, Cochran's Q test was used to assess heterogeneity, and leave-one-out sensitivity analysis was utilized to analyze the stability of the results.

Results: The results of MR analysis showed that tea intake was negatively associated with gout due to impairment of renal function (OR 0.997, 95% CI 0.994 to 0.999, P = 0.017), whereas there was no causal association with gout, idiopathic gout, and uric acid (P > 0.05), for which sensitivity analysis suggested that these results were robust.

Conclusions: There was a genetic predisposition effect of increased tea intake on the reduced risk of gout due to impairment of renal function, whereas there was no such effect on gout, idiopathic gout, and uric acid. Tea intake may become an important option in the dietary treatment of gout due to impairment of renal function.

Keywords: Mendelian randomization; caffeine; gout; gout due to impairment of renal function; tea intake; uric acid.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
MR design for causal analysis of tea intake on genetic predisposition to gout and uric acid.
Figure 2
Figure 2
MR flow chart for causal analysis of tea intake on genetic predisposition to gout and uric acid.
Figure 3
Figure 3
Forest plot of MR analysis for tea intake on genetic predisposition to gout and uric acid.
Figure 4
Figure 4
Scatter plot of MR analysis for tea intake on genetic predisposition to gout (A), gout due to impairment of renal function (B), idiopathic gout (C), uric acid (D).
See this image and copyright information in PMC

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References

    1. Dalbeth N, Gosling AL, Gaffo A, Abhishek A. Gout. Lancet (2021) 397(10287):1843–55. doi: 10.1016/S0140-6736(21)00569-9 - DOI - PubMed
    1. Singh JA, Gaffo A. Gout epidemiology and comorbidities. Semin Arthritis Rheum (2020) 50(3S):S11–6. doi: 10.1016/j.semarthrit.2020.04.008 - DOI - PubMed
    1. Roubenoff R. Gout and hyperuricemia. Rheum Dis Clin North Am (1990) 16(3):539–50. - PubMed
    1. Zhang Y, Yang R, Dove A, Li X, Yang H, Li S, et al. . Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study. BMC Med (2022) 20(1):138. doi: 10.1186/s12916-022-02341-0 - DOI - PMC - PubMed
    1. Stamp LK, Frampton C, Drake J, Doughty RN, Troughton RW, Richards AM. Associations of gout and baseline serum urate level with cardiovascular outcomes: analysis of the coronary disease cohort study. Arthritis Rheumatol (2019) 71(10):1733–8. doi: 10.1002/art.41007 - DOI - PubMed

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