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. 2024 Feb;76(1):1220-1223.
doi: 10.1007/s12070-023-04228-9. Epub 2023 Sep 22.

Successful Treatment of Extraosseous Plasmacytoma of the Oropharynx with Cervical Lymph Node Involvement

Nurul Amilin Jaafar  1 , Faezahtul Arbaeyah Hussain  2 , Norhafiza Mat Lazim  1
Affiliations

Successful Treatment of Extraosseous Plasmacytoma of the Oropharynx with Cervical Lymph Node Involvement

Nurul Amilin Jaafar et al. Indian J Otolaryngol Head Neck Surg. 2024 Feb.

Abstract

Extraosseous plasmacytoma, a rare plasma cell neoplasm, was observed in a 52-year-old male with uncommon presentation in the oropharynx with cervical lymph node involvement. The patient presented with dysphonia and left neck swelling. This case report primarily focuses on the management, resulting in a successful treatment through radiotherapy.

Keywords: Dysphonia; Lymph node; Oropharynx; Plasmacytoma; Radiotherapy.

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Conflict of interest statement

Conflict of InterestThe authors declared no conflict of interest.

Figures

Fig. 1
Fig. 1
a and b: Rigid direct laryngoscopy view of a mass arising from the left tonsil extending to the hypopharynx(*). The mass (#) abuts supraglottic structures posteriorly, obstructing the laryngeal inlet; c and d: Follow up was observed 2 months after radiotherapy
Fig. 2
Fig. 2
Head and neck MRI of the axial section T1-weighted showed a left oropharyngeal contrast-enhanced mass centered on the left tonsillar fossa (red arrow) measuring 5.4cmx3.2cmx5.8 cm with an enlarged and matted contrast-enhanced left lymph node (X), immediately posterior to the left carotid sheath and deep to the deep lobe of the left parotid gland, measuring 3.4cmx2.8cmx4.4 cm
Fig. 3
Fig. 3
A : diffuse plasma cells infiltration exhibiting eccentric located nuclei with eosinophilic cytoplasm (H&E, 100x). B : CD138 positive stain in the tumour cells, with different intensities. Confirming plasma cell linage. These cells are also negative for CD20, CD3 and CD56 (not shown). It has been reported that CD56 is often negative in extraosseous plasmacytoma [1] (40x). C : Kappa light chain (40x). D : Lambda light chain (40x). The different intensity and distribution of kappa compared to lambda staining indicated kappa light restriction. This observation is important for excluding reactive plasma cells
See this image and copyright information in PMC

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