Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb;76(1):1389-1397.
doi: 10.1007/s12070-023-04148-8. Epub 2023 Sep 1.

Prognostic Role of Neutrophil to Lymphocyte Ratio in Allergic Rhinitis: A Systematic Review and Meta-analysis

Monireh Khanzadeh  1 , Sima Foroughi Nematollahi  2 , Mitra Shavakhi  3 , Arshin Ghaedi  4 , Amirhossein Mallahi  4 , Aida Bazrgar  4 , Shokoufeh Khanzadeh  5
Affiliations

Prognostic Role of Neutrophil to Lymphocyte Ratio in Allergic Rhinitis: A Systematic Review and Meta-analysis

Monireh Khanzadeh et al. Indian J Otolaryngol Head Neck Surg. 2024 Feb.

Abstract

One of the crucial triggers of allergic diseases is an inflammatory reaction and neutrophil to lymphocyte ratio (NLR) is one of the systemic inflammation biomarkers. Our review aimed to evaluate role of NLR in predicting severity and comorbidities of allergic rhinitis (AR). We systematically searched Scopus, Web of Science, and PubMed to find relevant studies. Standardized mean difference (SMD) with a 95% confidence interval (CI) was reported. Due to the high levels of heterogeneity, the random-effects model was used to generate pooled effects. Eleven articles were included in the systematic review, among which ten were included in meta-analysis including 1122 healthy controls and 1423 patients with AR. We found that patients with AR had a significantly higher level of NLR than healthy controls (SMD = 0.19, 95%CI = 0.03-0.36, P = 0.03). In addition, patients with moderate to severe AR had significantly higher levels of NLR compared to those with mild AR (SMD = 0.41, 95%CI = 0.20-0.63, P < 0.001). Interestingly, it was found that NLR could associate with some comorbidities of AR, like asthma. Our results confirmed that NLR could assist clinicians in predicting the severity and comorbidities of AR.

Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-04148-8.

Keywords: Allergic rhinitis; Meta-analysis; NLR; Neutrophil to lymphocyte ratio.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestThe authors declare that there is no conflict of interest regarding the publication of this article.

Figures

Fig. 1
Fig. 1
PRISMA 2020 Flow diagram for new systematic reviews, which includes searches of databases, registers, and other sources
Fig. 2
Fig. 2
Meta-analysis of differences in NLR level between patients with AR and healthy controls
Fig. 3
Fig. 3
Meta-analysis of differences in NLR level between patients with moderate to severe AR and those with mild AR
Fig. 4
Fig. 4
Funnel plot assessing publication bias; A) Primary outcome: differences in NLR level between patients with moderate to severe AR and those with mild AR; B) Secondary outcome: the differences in NLR level between patients with AR and healthy controls
See this image and copyright information in PMC

References

    1. Passali D, et al. The international study of the allergic rhinitis survey: outcomes from 4 geographical regions. Asia Pacific Allerg. 2018 doi: 10.5415/apallergy.2018.8.e7. - DOI - PMC - PubMed
    1. Wise SK, et al. International consensus statement on allergy and rhinology: allergic rhinitis. Int Forum Allerg Rhinol. 2018;8(2):108–352. - PMC - PubMed
    1. Arasi S, et al. The future outlook on allergen immunotherapy in children: 2018 and beyond. Ital J Pediatr. 2018;44(1):1–9. doi: 10.1186/s13052-018-0519-4. - DOI - PMC - PubMed
    1. Dogru M, Citli R. The neutrophil-lymphocyte ratio in children with atopic dermatitis: a case-control study. Clin Ter. 2017;168(4):e262–e265. - PubMed
    1. Keskin H, et al. Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis. Endocr Regul. 2016;50(3):148–153. doi: 10.1515/enr-2016-0017. - DOI - PubMed

LinkOut - more resources