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Comment
. 2024 Mar;99(3):e13351.
doi: 10.1111/sji.13351. Epub 2024 Jan 16.

Concerns about the histological assessment in a mouse model of human celiac disease

Tobias L Freitag  1 , Leif C Andersson  2 , Anja Kipar  3   4
Affiliations
Comment

Concerns about the histological assessment in a mouse model of human celiac disease

Tobias L Freitag et al. Scand J Immunol. 2024 Mar.

Abstract

Commentary on: Abadie V et al. IL‐15, gluten and HLA‐DQ8 drive tissue destruction in coeliac disease. Nature. 2020; 578: 600‐604

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Comment on

  • IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.
    Abadie V, Kim SM, Lejeune T, Palanski BA, Ernest JD, Tastet O, Voisine J, Discepolo V, Marietta EV, Hawash MBF, Ciszewski C, Bouziat R, Panigrahi K, Horwath I, Zurenski MA, Lawrence I, Dumaine A, Yotova V, Grenier JC, Murray JA, Khosla C, Barreiro LB, Jabri B. Abadie V, et al. Nature. 2020 Feb;578(7796):600-604. doi: 10.1038/s41586-020-2003-8. Epub 2020 Feb 12. Nature. 2020. PMID: 32051586 Free PMC article.

References

REFERENCES

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    1. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology. 1992;102:330‐354.
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    1. de Kauwe AL, Chen Z, Anderson RP, et al. Resistance to celiac disease in humanized HLA‐DR3‐DQ2‐transgenic mice expressing specific anti‐gliadin CD4+ T cells. J. Immunol. 2009;182:7440‐7450.
    1. Black KE, Murray JA, David CS. HLA‐DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J. Immunol. 2002;169:5505‐5600.

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