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Review
. 2024 May 1;30(3):294-302.
doi: 10.1097/MCP.0000000000001073. Epub 2024 Mar 4.

Obesity-related asthma: new insights leading to a different approach

Adjan Witte  1 , Yasemin Türk  1   2 , Gert-Jan Braunstahl  1   3
Affiliations
Review

Obesity-related asthma: new insights leading to a different approach

Adjan Witte et al. Curr Opin Pulm Med. .

Abstract

Purpose of review: Obesity is a growing global health threat that significantly contributes to the burden of asthma by increasing the risk of developing asthma and exerting a distinct effect on lung function and inflammation. The treatment of obesity-related asthma is hindered by a poor response to standard asthma treatments, leading to worse asthma control. Weight loss strategies have a significant effect on asthma symptoms but are not feasible for a large proportion of patients, underscoring the need for a better understanding of the pathophysiology and the development of additional treatment options.

Recent findings: Recent literature focusing on pathophysiology particularly delved into nontype 2 inflammatory mechanisms, associations with the metabolic syndrome and small airway impairment. Additionally, several new treatment options are currently investigated, including biologics, weight reduction interventions, and novel antiobesity drugs.

Summary: Obesity-related asthma is a highly prevalent asthma phenotype for which weight loss strategies currently stand as the most specific treatment. Furthermore, novel pharmacological interventions aiming at metabolic processes are on the way.

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