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Review
. 2024 Mar 5;15(1):62.
doi: 10.1007/s12672-024-00908-2.

The impact of radiomics in the management of soft tissue sarcoma

Riccardo De Angelis #  1   2 , Roberto Casale #  3   4 , Nicolas Coquelet  1 , Samia Ikhlef  1   2 , Ayoub Mokhtari  5   6 , Paolo Simoni  2 , Maria Antonietta Bali  1   2
Affiliations
Review

The impact of radiomics in the management of soft tissue sarcoma

Riccardo De Angelis et al. Discov Oncol. .

Abstract

Introduction: Soft tissue sarcomas (STSs) are rare malignancies. Pre-therapeutic tumour grading and assessment are crucial in making treatment decisions. Radiomics is a high-throughput method for analysing imaging data, providing quantitative information beyond expert assessment. This review highlights the role of radiomic texture analysis in STSs evaluation.

Materials and methods: We conducted a systematic review according to the Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in PubMed/MEDLINE and Scopus using the search terms: 'radiomics [All Fields] AND ("soft tissue sarcoma" [All Fields] OR "soft tissue sarcomas" [All Fields])'. Only original articles, referring to humans, were included.

Results: A preliminary search conducted on PubMed/MEDLINE and Scopus provided 74 and 93 studies respectively. Based on the previously described criteria, 49 papers were selected, with a publication range from July 2015 to June 2023. The main domains of interest were risk stratification, histological grading prediction, technical feasibility/reproductive aspects, treatment response.

Conclusions: With an increasing interest over the last years, the use of radiomics appears to have potential for assessing STSs from initial diagnosis to predicting treatment response. However, additional and extensive research is necessary to validate the effectiveness of radiomics parameters and to integrate them into a comprehensive decision support system.

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Conflict of interest statement

No conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
An illustrative radiomics workflow applied to a left thigh myxoid fibrosarcoma
Fig. 2
Fig. 2
Selection process of literature
Fig. 3
Fig. 3
Participant centres of included articles
Fig. 4
Fig. 4
Imaging techniques of included articles
Fig. 5
Fig. 5
Domains of interest covered by the selected articles
See this image and copyright information in PMC

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