Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 5;19(3):e0299026.
doi: 10.1371/journal.pone.0299026. eCollection 2024.

Peripheral immune cell traits and Parkinson's disease: A Mendelian randomization study

Jie Tian  1 , Chunyan Zuo  2 , Jingjing Shi  2 , Dongrui Ma  2 , Changhe Shi  2
Affiliations

Peripheral immune cell traits and Parkinson's disease: A Mendelian randomization study

Jie Tian et al. PLoS One. .

Abstract

Background: The peripheral immune system is altered in Parkinson's disease (PD), but the causal relationship between the two remains controversial. In this study, we aimed to estimate the causal relationship between peripheral immune features and PD using a two-sample Mendelian randomization (MR) approach.

Methods: Genome-wide association study (GWAS) data of peripheral blood immune signatures from European populations were used for exposure and PD summary statistics were used as results. We conducted a two-sample MR study using the inverse-variance weighted (IVW), MR-Egger, and weighted median methods to evaluate the causal association between these factors. MR-Egger and MR-PRESSO were used for sensitivity analysis to test and correct horizontal pleiotropy.

Results: A total of 731 immune traits were analyzed for association with PD using three MR methods. After adjustment for FDR, we observed four peripheral immunological features associated with PD using the IVW method, including expression of CX3CR1 on monocytes [OR: 0.85, 95% CI: (0.81, 0.91), P = 6.56E-07] and CX3CR1 on CD14+CD16+ monocytes [OR: 0.87, 95% CI: (0.82, 0.93), P = 9.95E-06].

Conclusions: Our study further revealed the important role of monocytes in PD and indicated that CX3CR1 expression on monocytes is associated with a reduced risk of PD.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Scatter plot showing the causal effect of CX3CR1 on monocytes on Parkinson’s disease.
MR, Mendelian Randomization.
Fig 2
Fig 2. Scatter plot showing the causal effect of CX3CR1 on CD14+ CD16+ monocyte on Parkinson’s disease.
MR, Mendelian Randomization.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Tolosa E, Garrido A, Scholz SW, Poewe W. Challenges in the diagnosis of Parkinson’s disease. Lancet Neurol. 2021;20(5):385–97. Epub 2021/04/25. doi: 10.1016/S1474-4422(21)00030-2 ; PubMed Central PMCID: PMC8185633. - DOI - PMC - PubMed
    1. Fereshtehnejad SM, Zeighami Y, Dagher A, Postuma RB. Clinical criteria for subtyping Parkinson’s disease: biomarkers and longitudinal progression. Brain. 2017;140(7):1959–76. Epub 2017/05/27. doi: 10.1093/brain/awx118 . - DOI - PubMed
    1. Jankovic J, Tan EK. Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry. 2020;91(8):795–808. Epub 2020/06/25. doi: 10.1136/jnnp-2019-322338 . - DOI - PubMed
    1. Ascherio A, Schwarzschild MA. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol. 2016;15(12):1257–72. Epub 2016/10/19. doi: 10.1016/S1474-4422(16)30230-7 . - DOI - PubMed
    1. Pajares, A IR, Manda G, Boscá L, Cuadrado A. Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications. Cells. 2020;9(7). Epub 2020/07/18. doi: 10.3390/cells9071687 ; PubMed Central PMCID: PMC7408280. - DOI - PMC - PubMed