Ocular immunology and inflammation under microgravity conditions and the pathogenesis of spaceflight associated neuro-ocular syndrome (SANS)

Mouayad Masalkhi¹, Joshua Ong², Ethan Waisberg³, Andrew G Lee^{4

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Affiliations

¹ University College Dublin School of Medicine, Belfield, Dublin, Ireland. mouayad.masalkhi@ucdconnect.ie.
² Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
³ Department of Ophthalmology, University of Cambridge, Cambridge, UK.
⁴ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
⁵ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
⁶ The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
⁷ Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA.
⁸ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
⁹ University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁰ Texas A&M College of Medicine, Bryan, TX, USA.
¹¹ Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Mouayad Masalkhi et al. Eye (Lond). 2024 Jul.

. 2024 Jul;38(10):1799-1801.

doi: 10.1038/s41433-024-03005-4. Epub 2024 Mar 5.

Mouayad Masalkhi¹, Joshua Ong², Ethan Waisberg³, Andrew G Lee^{4

5

6

7

8

9

10

11}

¹ University College Dublin School of Medicine, Belfield, Dublin, Ireland. mouayad.masalkhi@ucdconnect.ie.
² Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
³ Department of Ophthalmology, University of Cambridge, Cambridge, UK.
⁴ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
⁵ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
⁶ The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
⁷ Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA.
⁸ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
⁹ University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁰ Texas A&M College of Medicine, Bryan, TX, USA.
¹¹ Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

No abstract available

Conflict of interest statement

The authors declare no competing interests.

Accelerated aging in space and the ocular surface.
Sampige R, Ong J, Waisberg E, Berdahl J, Lee AG. Sampige R, et al. Eye (Lond). 2024 Oct;38(14):2674-2676. doi: 10.1038/s41433-024-03143-9. Epub 2024 May 24. Eye (Lond). 2024. PMID: 38789786 No abstract available.
Sleep and optic disc edema in spaceflight associated neuro-ocular syndrome (SANS).
Nguyen T, Ong J, Waisberg E, Lee AG. Nguyen T, et al. Eye (Lond). 2024 Oct;38(14):2668-2670. doi: 10.1038/s41433-024-03119-9. Epub 2024 May 23. Eye (Lond). 2024. PMID: 38778142 No abstract available.

1. Waisberg E, Ong J, Lee AG. Factors Associated With Optic Disc Edema Development During Spaceflight. JAMA Ophthalmol. 2023; Available from: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2802691. - PubMed
1. Ong J, Waisberg E, Masalkhi M, Kamran SA, Lowry K, Sarker P, et al. Artificial Intelligence Frameworks to Detect and Investigate the Pathophysiology of Spaceflight Associated Neuro-Ocular Syndrome (SANS) Brain Sci. 2023;13:1148. doi: 10.3390/brainsci13081148. - DOI - PMC - PubMed
1. Masalkhi M, Ong J, Waisberg E, Lee AG. Chorioretinal folds in astronauts: risk of chorioretinal fold-related maculopathy and terrestrial staging of disease. Eye. 2023; Available from: https://www.nature.com/articles/s41433-023-02730-6. - PMC - PubMed
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