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. 2024 May;32(5):999-1008.
doi: 10.1002/oby.23999. Epub 2024 Mar 5.

The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16

Takahiro Ichikawa  1 , Hiroshi Okada  1   2 , Masahide Hamaguchi  1 , Norihiro Nishioka  3 , Yukiko Tateyama  3 , Tomonari Shimamoto  3 , Kazushiro Kurogi  4 , Hiroaki Murata  5 , Masato Ito  4 , Taku Iwami  3 , Michiaki Fukui  1
Affiliations

The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16

Takahiro Ichikawa et al. Obesity (Silver Spring). 2024 May.

Abstract

Objective: The study objective was to investigate whether changes in metabolic phenotype affect the risk of cardiovascular events.

Methods: All 117,589 participants were included in this retrospective cohort study. The metabolic phenotypes of the participants were assessed at two points (the second evaluation was set 2 years after the first evaluation), and the incidence rate of cardiovascular events was observed for 11 years. The main outcome was 3-point major adverse cardiac events (MACE), which comprises cardiovascular death, nonfatal coronary artery disease, and nonfatal stroke incidence.

Results: Of the participants, 2748 (2.3%) cases of 3-point MACE were identified during follow-up. The stable metabolically healthy obesity group had a higher risk of 3-point MACE than those with stable metabolically healthy nonobesity (MHNO). Additionally, the change from metabolically healthy obesity to MHNO for 2 years decreased the risk of 3-point MACE (hazard ratio [HR], 1.12: 95% CI: 0.84-1.47) to the same level as stable MHNO. However, the change from metabolically abnormal nonobesity and metabolically abnormal obesity to MHNO for 2 years maintained a higher risk of 3-point MACE (HR, 1.66 [95% CI: 1.36-2.01]; HR, 1.91 [95% CI: 1.22-2.81]) than those with stable MHNO.

Conclusions: Change in metabolic phenotype is associated with incident 3-point MACE.

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References

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