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Review
. 2024 Jan 1;28(1):8-14.
doi: 10.61186/ibj.4028. Epub 2023 Dec 2.

Celiac Disease: A Review from Genetic to Treatment

Erfaneh Jafari  1 , Niloufar Soleymani  2 , Masoud Hamidi  3 , Azar Rahi  4 , Akram Rezaei  5 , Reza Azizian  1   6
Affiliations
Review

Celiac Disease: A Review from Genetic to Treatment

Erfaneh Jafari et al. Iran Biomed J. .

Abstract

Celiac disease (CD) is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.

Keywords: Celiac disease; Dipeptidyl peptidase 4; HLA-DQ antigens; Probiotics.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Roles attributed to DPP4
See this image and copyright information in PMC

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