Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb 25;10(5):e27125.
doi: 10.1016/j.heliyon.2024.e27125. eCollection 2024 Mar 15.

Microbiota substances modulate dendritic cells activity: A critical view

Yuliia Shvets  1 , Natalia Khranovska  2 , Natalia Senchylo  1 , Danylo Ostapchenko  1 , Iryna Tymoshenko  3 , Svitlana Onysenko  1 , Nazarii Kobyliak  3   4 , Tetyana Falalyeyeva  1   4
Affiliations
Review

Microbiota substances modulate dendritic cells activity: A critical view

Yuliia Shvets et al. Heliyon. .

Abstract

Contemporary research in the field of microbiota shows that commensal bacteria influence physiological activity of different organs and systems of a human organism, such as brain, lungs, immune and metabolic systems. This influence is realized by various processes. One of them is trough modulation of immune mechanisms. Interactions between microbiota and the human immune system are known to be complex and ambiguous. Dendritic cells (DCs) are unique cells, which initiate the development and polarization of adaptive immune response. These cells also interconnect native and specific immune reactivity. A large set of biochemical signals from microbiota in the form of different microbiota associated molecular patterns (MAMPs) and bacterial metabolites that act locally and distantly in the human organism. As a result, commensal bacteria influence the maturity and activity of dendritic cells and affect the overall immune reactivity of the human organism. It then determines the response to pathogenic microorganisms, inflammation, associated with different pathological conditions and even affects the effectiveness of vaccination.

Keywords: Antigen presenting cells; Autoinducer; Commensal bacteria; Lipopolysaccharide; Peptidoglycan; Secondary bile acid; Short chain fatty acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Bacterial MAMPs, metabolites, and cellular components. OMV – outer membrane vesicles, SCFAs – short chin fatty acids, AA – acidic acid, PA – propionic acid, BA – butyric acid; SBA – secondary bile acids; AI – autoinducers, MDP – muramyldipeptide, AHL – acyl homoseryne lactone. Residues are indicated as hexagons: GlcN, glucosamine; Kdo, 3-deoxy-d-manno-oct-2-ulosonic acid; Hep, l-glycero-dmanno-heptose; Gal, Galactose; Glu, Glucose. Phosphate groups are indicated as circled P.
Fig. 2
Fig. 2
Scheme of LPS and PGN influence DCs maturation and function in vitro.
Fig. 3
Fig. 3
Primary bile acids conversion by microbiota to secondary bile acids, bile acid metabolites, and their impact on DCs. EC – epithelial cells, Mph – macrophages, NK – natural killer cells.
Fig. 4
Fig. 4
Proposed simplified model of microbial signals impact on DCs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. The integrative human microbiome project. Nature. 2019;569:641–648. doi: 10.1038/s41586-019-1238-8. - DOI - PMC - PubMed
    1. Plichta D.R., Juncker A.S., Bertalan M., Rettedal E., Gautier L., Varela E., Manichanh C., Fouqueray C., Levenez F., Nielsen T., Doré J., Machado A.M.D., de Evgrafov M.C.R., Hansen T., Jørgensen T., Bork P., Guarner F., Pedersen O., Sommer M.O.A., Ehrlich S.D., Sicheritz-Pontén T., Brunak S., Nielsen H.B. Transcriptional interactions suggest niche segregation among microorganisms in the human gut. Nat. Microbiol. 2016;1 doi: 10.1038/nmicrobiol.2016.152. - DOI - PubMed
    1. Lloyd-Price J., Mahurkar A., Rahnavard G., Crabtree J., Orvis J., Hall A.B., Brady A., Creasy H.H., McCracken C., Giglio M.G., McDonald D., Franzosa E.A., Knight R., White O., Huttenhower C. Strains, functions and dynamics in the expanded human microbiome project. Nature. 2017;550:61–66. doi: 10.1038/nature23889. - DOI - PMC - PubMed
    1. Park D.-Y., Park J.Y., Lee D., Hwang I., Kim H.-S. Leaky gum: the revisited origin of systemic diseases. Cells. 2022;11(7):1079. doi: 10.3390/cells11071079. - DOI - PMC - PubMed
    1. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019;68(8):1516–1526. doi: 10.1136/gutjnl-2019-318427. - DOI - PMC - PubMed