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. 2024 Feb 20:14:1294383.
doi: 10.3389/fonc.2024.1294383. eCollection 2024.

Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study

Weiqing Han #  1 , Silin Wang #  2 , Lang Su  2 , Jianjun Xu  1 , Yiping Wei  2
Affiliations

Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study

Weiqing Han et al. Front Oncol. .

Abstract

Background: As lung squamous cell carcinoma (LUSC) patients are at increased risk of developing a second primary cancer, this complicates the patient's condition and thus makes prognostic assessment more difficult, posing a significant prognostic challenge for clinicians. Our goal was to assess the prognosis of LUSC patients with a second primary tumor, and provide insights into appropriate therapy and monitoring strategies.

Methods: Data was obtained for LUSC patients from the Surveillance, Epidemiology, and End Results (SEER) database. The LUSC patients were divided into three groups (LS-SPM, OT-LUSC and LUSC-only). Univariate and stratified analyses were performed for the baseline and clinical characteristics of the participants. Multiple regression and Kaplan-Meier survival analyses were also performed, followed by a final life table analysis.

Results: In our sample of 101,626 patients, the HR for OS in the LS-SPM group was 0.40 in univariate analysis. Kaplan-Meier survival curves showed that LS-SPM patients had considerably longer lifespans compared to the other groups. The LS-SPM patients had median and mean survival times of 64 months and 89.11 months. Unadjusted and adjusted multiple regression analyses showed that LS-SPM patients had a superior survival compared to LUSC-only and OT-LUSC groups.

Conclusion: LS-SPM patients have a good prognosis with aggressive therapy and immune monitoring. The present study offers novel insights into the pathophysiological causes and treatments for LS-SPM.

Keywords: NSCLC; SEER; lung squamous cell carcinoma; second primary malignancy; survival time.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Data screening chart with LUSC patients.
Figure 2
Figure 2
Kaplan-Meier survival curves for LUSCs.
Figure 3
Figure 3
Kaplan-Meier survival curves for LUSC covariates, including sex (A), age (B), race (C), grade (D), primary site (E), historic stage (F), positive regional nodes (G), laterality (H), marital status (I), radiation (J), surgery (K), chemotherapy (L), year of diagnosis (M), and duration in months between diagnosis and treatment (N). LUSC, lung squamous cell carcinoma.
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