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. 2024 Mar 1:20:449-458.
doi: 10.2147/NDT.S447851. eCollection 2024.

Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients

Wenpei Wu #  1   2 , Zhi Geng #  3   4   5 , Aimei Wu #  2 , Xinyi Chen  6   7 , Xiaoying Meng  2 , Qianyun Zhang  2 , Zheng Tan  2 , Hong Yue  2 , Juncang Wu  1   2
Affiliations

Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients

Wenpei Wu et al. Neuropsychiatr Dis Treat. .

Abstract

Background and purpose: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH).

Methods: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference in UA levels between patients with a good prognosis and those with a poor prognosis. Additionally, we analyzed the impact of UA levels on the risk of short-time prognosis of ICH patients.

Results: Patients with a good prognosis presented with significantly lower levels of UA (348.71 ± 84.97 μmol/L) than those with poor prognosis (393.06 ± 148.46 μmol/L). Furthermore, multivariate logistic regression model demonstrated that a high UA level was a likely risk factor for worse prognosis among patients suffering in ICH (odds ratio [95% confidence interval], 1.006 [1.0012, 1.0108]; P = 0.015). Additionally, UA has a threshold effect value of 363.9 μmol/L and was presented in levels that were in a nonlinear relationship with incidence rate of short-time prognosis outcome of ICH patients.

Conclusion: Our findings indicate that higher UA levels can increase the risk of poor clinical prognosis in patients with ICH and high UA levels are not conductive to the clinical prognosis of patients with ICH. These findings provide a new perspective on the treatment and prevention of ICH.

Keywords: follow-up; intracerebral hemorrhage; nonlinear relationship; oxidative stress; prognosis; uric acid.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of patient inclusion and analysis.
Figure 2
Figure 2
The threshold effect of uric acid levels on short-time prognosis outcome of ICH patients.
See this image and copyright information in PMC

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