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Review
. 2024;16(8):279-305.
doi: 10.4155/bio-2023-0256. Epub 2024 Mar 6.

Covalent organic frameworks: spotlight on applications in the pharmaceutical arena

Pushpa Pilli  1 , Hema Sree Kommalapati  1 , Vijaya Madhyanapu Golla  1 , Rahul Khemchandani  1 , Roshitha Kunnath Ramachandran  1 , Gananadhamu Samanthula  1
Affiliations
Review

Covalent organic frameworks: spotlight on applications in the pharmaceutical arena

Pushpa Pilli et al. Bioanalysis. 2024.

Abstract

Covalent organic frameworks (COFs) have much potential in the field of analytical separation research due to their distinctive characteristics, including easy modification, low densities, large specific surface areas and permanent porosity. This article provides a historical overview of the synthesis and broad perspectives on the applications of COFs. The use of COF-based membranes in gas separation, water treatment (desalination, heavy metals and dye removal), membrane filtration, photoconduction, sensing and fuel cells is also covered. However, these COFs also demonstrate great promise as solid-phase extraction sorbents and solid-phase microextraction coatings. In addition to various separation applications, this work aims to highlight important advancements in the synthesis of COFs for chiral and isomeric compounds.

Keywords: capillary electrochromatography; covalent organic frameworks; gas chromatography; high-performance liquid chromatography; solid-phase microextraction.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Figures

Figure 1.
Figure 1.
Self-condensation of 1,4-benzenediboronic acid to produce covalent organic framework-1 with proposed crystalline structure.
Figure 2.
Figure 2.
Pharmaceutical applications of covalent organic frameworks.
Figure 3.
Figure 3.
Integration of covalent organic frameworks and metal-organic frameworks.
See this image and copyright information in PMC

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