Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 6;12(3).
doi: 10.2106/JBJS.RVW.23.00224. eCollection 2024 Mar 1.

Surgical Margins in Musculoskeletal Sarcoma

Julia C Quirion  1 , Samuel R Johnson  1 , Brooke L Kowalski  1 , Jennifer L Halpern  1 , Herbert S Schwartz  1 , Ginger E Holt  1 , Carlos Prieto-Granada  2 , Reena Singh  2 , Justin M M Cates  3 , Brian P Rubin  4 , Nathan W Mesko  5 , Lukas M Nystrom  5 , Joshua M Lawrenz  1
Affiliations

Surgical Margins in Musculoskeletal Sarcoma

Julia C Quirion et al. JBJS Rev. .

Abstract

» Negative margin resection of musculoskeletal sarcomas is associated with reduced risk of local recurrence.» There is limited evidence to support an absolute margin width of soft tissue or bone that correlates with reduced risk of local recurrence.» Factors intrinsic to the tumor, including histologic subtype, grade, growth pattern and neurovascular involvement impact margin status and local recurrence, and should be considered when evaluating a patient's individual risk after positive margins.» Appropriate use of adjuvant therapy, critical analysis of preoperative advanced cross-sectional imaging, and the involvement of a multidisciplinary team are essential to obtain negative margins when resecting sarcomas.

PubMed Disclaimer

Conflict of interest statement

Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/B67).

References

    1. Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB, Pritchard J, Malpas JS, Baker AR, Kirkpatrick JA. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314(25):1600-6.
    1. Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN, Topalian SL, DeLaney T, Glatstein E, Steinberg SM, Merino MJ, Rosenberg SA. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16(1):197-203.
    1. DiCaprio MR, Friedlaender GE. Malignant bone tumors: limb sparing versus amputation. J Am Acad Orthop Surg. 2003;11(1):25-37.
    1. Dickinson IC, Whitwell DJ, Battistuta D, Thompson B, Strobel N, Duggal A, Steadman P. Surgical margin and its influence on survival in soft tissue sarcoma. ANZ J Surg. 2006;76(3):104-9.
    1. Hoang K, Gao Y, Miller BJ. The variability in surgical margin reporting in limb salvage surgery for sarcoma. Iowa Orthop J. 2015;35:181-6.

LinkOut - more resources