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Comment
. 2024 Mar 5;36(3):457-458.
doi: 10.1016/j.cmet.2024.02.005.

Itaconate boosts malaria via induction of PD-L1

Yukun Min  1 , Luke A J O'Neill  2
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Itaconate boosts malaria via induction of PD-L1

Yukun Min et al. Cell Metab. .
Free article

Abstract

The Krebs-cycle-derived metabolite itaconate has been shown to be immunomodulatory, targeting multiple processes in macrophages. Ramalho et al. reveal an additional role for itaconate in malaria.1Plasmodium Chabaudi induces itaconate in dendritic cells (DCs), leading to programmed death-ligand 1 (PD-L1) induction. This suppresses CD8+ T cells, important for host defense against malaria, thereby promoting parasitemia.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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