Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr;38(4):2188-2196.
doi: 10.1007/s00464-024-10748-4. Epub 2024 Mar 6.

Impact of endoscopic surveillance on the early diagnosis and endoscopic resection likelihood of gastric cancer

Lu Sun  1 , Yanjie Shen  1 , Liang Huang  2 , Jing Zhao  1 , Meng Li  1 , Yue Hu  1 , Bin Lyu  3   4
Affiliations

Impact of endoscopic surveillance on the early diagnosis and endoscopic resection likelihood of gastric cancer

Lu Sun et al. Surg Endosc. 2024 Apr.

Abstract

Background: Endoscopy could help detect early gastric cancer (EGC) and improve the prognosis of patients. The aim of this study was to analyze the impact of endoscopy and endoscopic surveillance on the early detection of gastric cancer (GC), GC staging, and treatment selection.

Methods: Patients with GC diagnosed at our center from 2010 to 2022 were retrospectively analyzed and allocated to the short-interval group (had received endoscopy within 3 years before diagnosis), the long-interval group (had received endoscopy more than 3 years before diagnosis), and the unchecked group (had not received endoscopy before diagnosis). The differences in GC staging and treatment modalities among the three groups were analyzed, and the differences in the clinical and pathological features of EGC were further analyzed.

Results: One thousand and twenty-five GC patients were included, with 395 cases of EGC and 630 cases of advanced GC. The proportions of EGC in the short-interval, long-interval, and unchecked groups were 98.0%, 84.2%, and 29.8%, respectively (p < 0.001). Among the 387 lesions of 367 EGC patients were resected by endoscopic submucosal dissection (ESD), 341 (88.1%) exhibited curative resection, and 46 (11.9%) involved noncurative resections. Lesions of EGC differed significantly in diameter, depth of invasion, and curative resection rate (p = 0.033, 0.019, and 0.005, respectively). In the short-interval group, 87.8% of the lesions were ≤ 2 cm, 95.6% of the invasion depths were confined to the mucosal layer, and 96.7% of the eCura scores were A or B. Compared with the unchecked group, they had smaller diameters (RR = 0.419, 95% CI 0.234-0.752), shallower invasion depths (RR = 0.286, 95% CI 0.105-0.777), and a higher curative resection rate (RR = 0.215, 95% CI 0.068-0.676).

Conclusion: Endoscopic surveillance at 3-year intervals can help detect EGC, and the EGC lesions found have smaller diameters and shallower depths of invasion, helping improve the curative resection rate of ESD.

Keywords: Early detection of cancer; Endoscopic submucosal dissection; Endoscopy; Gastric cancer; Gastric precancerous conditions.

PubMed Disclaimer

References

    1. Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249 - DOI - PubMed
    1. Xia C, Dong X, Li H et al (2022) Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J 135(05):584–590 - DOI - PubMed - PMC
    1. Yang L, Ying X, Liu S et al (2020) Gastric cancer: epidemiology, risk factors and prevention strategies. Chin J Cancer Res 32(6):695 - DOI - PubMed - PMC
    1. Machlowska J, Maciejewski R, Sitarz R (2018) The pattern of signatures in gastric cancer prognosis. Int J Mol Sci 19(6):1658 - DOI - PubMed - PMC
    1. Allemani C, Matsuda T, Di Carlo V et al (2018) Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. The Lancet 391(10125):1023–1075 - DOI

Publication types

LinkOut - more resources