Burkitt's Lymphoma of the Breast in an HIV-Positive Patient: A Rare Presentation

Abstract

Introduction: Breast cancer is the most common female cancer worldwide, affecting 13.5-30 per 100,000 women in sub-Saharan Africa. The most common histopathologic variants of breast cancer are those that originate from the glandular epithelium of the breast. Primary breast lymphomas are uncommon, and they represent only 0.04%-0.5% of all breast cancers. Burkitt lymphoma is the least of this rare group. The report intends to present Burkitt's lymphoma, a rare histopathological diagnosis of primary breast tumour in an HIV+ patient. Description of a case of bilateral breast disease and the histopathologic diagnosis. Our case was a 28-year-old HIV+ woman who presented with multiple bilateral breast lumps for 2 months duration, associated with bilateral axillary lumps, weight loss, night sweat, and malaise. Lumps range from 2 to 8 cm in size with multiple axillary lymph nodes. Core tissue biopsy showed a monotonous population of intermediate-sized lymphoid cells with round nuclei, clumped chromatin, and several nucleoli interspersed by numerous tangible body macrophages, presenting a starry-sky appearance. Diagnosis of bilateral primary breast Burkitt's lymphoma was performed, and the patient was referred to oncology. She was placed on antiretroviral therapy and chemotherapy (cyclophosphamide, hydroxydaunorubicin, vincristine sulphate, and prednisone) and clinically responded to therapy.

Conclusions: Breast lumpiness in immunocompromised patients calls for the suspicion of lymphoma.

Keywords: Breast lumps; Burkitt’s lymphoma; Immunocompromised.

Figure 1

Micrograph of Burkitt lymphoma of the breast with pathognomonic starry-sky appearance (power 1 × 100) H&E