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Review
. 2024 Feb 21:18:1346184.
doi: 10.3389/fnins.2024.1346184. eCollection 2024.

The role of gut microorganisms and metabolites in intracerebral hemorrhagic stroke: a comprehensive review

Xin Wen  1 , Hao Dong  1 , Wei Zou  2
Affiliations
Review

The role of gut microorganisms and metabolites in intracerebral hemorrhagic stroke: a comprehensive review

Xin Wen et al. Front Neurosci. .

Abstract

Intracerebral hemorrhagic stroke, characterized by acute hemorrhage in the brain, has a significant clinical prevalence and poses a substantial threat to individuals' well-being and productivity. Recent research has elucidated the role of gut microorganisms and their metabolites in influencing brain function through the microbiota-gut-brain axis (MGBA). This article provides a comprehensive review of the current literature on the common metabolites, short-chain fatty acids (SCFAs) and trimethylamine-N-oxide (TMAO), produced by gut microbiota. These metabolites have demonstrated the potential to traverse the blood-brain barrier (BBB) and directly impact brain tissue. Additionally, these compounds have the potential to modulate the parasympathetic nervous system, thereby facilitating the release of pertinent substances, impeding the buildup of inflammatory agents within the brain, and manifesting anti-inflammatory properties. Furthermore, this scholarly analysis delves into the existing dearth of investigations concerning the influence of gut microorganisms and their metabolites on cerebral functions, while also highlighting prospective avenues for future research.

Keywords: NLRP3 inflammasome; ghrelin; intracerebral hemorrhage; microbiota-gut-brain axis; short-chain fatty acids; trimethylamine N-oxide.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of the microbiota-gut-brain axis (ICH) acting on the brain after intracerebral hemorrhage (ICH).
See this image and copyright information in PMC

References

    1. Abdelhamid M., Zhou C., Jung C. G., Michikawa M. (2022). Probiotic Bifidobacterium breve MCC1274 mitigates Alzheimer's disease-related pathologies in wild-type mice. Nutrients 14:543. doi: 10.3390/nu14122543, PMID: - DOI - PMC - PubMed
    1. Adams J. M., Cory S. (1998). The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322–1326. doi: 10.1126/science.281.5381.1322, PMID: - DOI - PubMed
    1. Agus A., Planchais J., Sokol H. (2018). Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23, 716–724. doi: 10.1016/j.chom.2018.05.003, PMID: - DOI - PubMed
    1. Aloisi F. (2001). Immune function of microglia. Glia 36, 165–179. doi: 10.1002/glia.1106 - DOI - PubMed
    1. An S. J., Kim T. J., Yoon B. W. (2017). Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: An update. J Stroke 19, 3–10. doi: 10.5853/jos.2016.00864, PMID: - DOI - PMC - PubMed

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