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. 2024 Feb 21:15:1292828.
doi: 10.3389/fphar.2024.1292828. eCollection 2024.

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

Xian Zhao  1 , Qin Peng  2 , Dongmei Hu  1 , Weiwei Li  1 , Qing Ji  1 , Qianqian Dong  1 , Luguang Huang  3 , Miyang Piao  1 , Yi Ding  1 , Jingwen Wang  1
Affiliations

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

Xian Zhao et al. Front Pharmacol. .

Abstract

Background: Based on real-world medical data, the artificial neural network model was used to predict the risk factors of linezolid-induced thrombocytopenia to provide a reference for better clinical use of this drug and achieve the timely prevention of adverse reactions. Methods: The artificial neural network algorithm was used to construct the prediction model of the risk factors of linezolid-induced thrombocytopenia and further evaluate the effectiveness of the artificial neural network model compared with the traditional Logistic regression model. Results: A total of 1,837 patients receiving linezolid treatment in a hospital in Xi 'an, Shaanxi Province from 1 January 2011 to 1 January 2021 were recruited. According to the exclusion criteria, 1,273 cases that did not meet the requirements of the study were excluded. A total of 564 valid cases were included in the study, with 89 (15.78%) having thrombocytopenia. The prediction accuracy of the artificial neural network model was 96.32%, and the AUROC was 0.944, which was significantly higher than that of the Logistic regression model, which was 86.14%, and the AUROC was 0.796. In the artificial neural network model, urea, platelet baseline value and serum albumin were among the top three important risk factors. Conclusion: The predictive performance of the artificial neural network model is better than that of the traditional Logistic regression model, and it can well predict the risk factors of linezolid-induced thrombocytopenia.

Keywords: ADR; ANN; linezolid; logistic regression; risk factor; thrombocytopenia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of studies predicting risk factors for linezolid-induced thrombocytopenia.
FIGURE 2
FIGURE 2
Structural diagram of ANN model for predicting the risk of thrombocytopenia caused by linezolid.
FIGURE 3
FIGURE 3
Training loss and AUC on validation dataset of ANN model during training process.
FIGURE 4
FIGURE 4
The ROC curves and AUCs of ANN and Logistic models on test dataset.
FIGURE 5
FIGURE 5
The importance and ranking diagram of potential risk factors in ANN model.
See this image and copyright information in PMC

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