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. 2024 Feb 28:2024:8852876.
doi: 10.1155/2024/8852876. eCollection 2024.

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Maria Tizu  1   2 , Bogdan Calenic  1 , Mihai Hârza  1   2 , Bogdan M Cristea  1 , Ion Maruntelu  2 , Andreea M Caragea  1 , Adriana Talangescu  2 , Alina Dima  3 , Alexandra E Constantinescu  1 , Ileana Constantinescu  1   2
Affiliations

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Maria Tizu et al. Genet Res (Camb). .

Abstract

Materials and methods: This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology.

Results: Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1∗04:02:01 (p=0.001, OR = 1.05) and HLA-DRB3∗02:01:01 (p=0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A∗24:02:01 0.01 (p=0.01, OR = 0.38), HLA-DQA1∗05:05:01 (p=0.01, OR = 0.56), HLA-DQB1∗03:02:01 (p=0.03, OR = 0.40), and HLA-DRB4∗01:03:01 (p=0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men.

Conclusions: Our data are the first to indicate that in Romanian patients with CLL, the HLA-A∗24:02:01 and HLA-DQA1∗05:05:01 alleles have a protective role against CLL development, whereas HLA-DRB1∗04:02:01 and HLA-DRB3∗02:01:01alleles are positively associated with CLL.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
∗ Significant HLA allelic associations for CLL patients. Significant HLA alleles for the CLL group of patients are represented with green, for women with CLL are represented in blue and for men with CLL are represented with yellow.
See this image and copyright information in PMC

References

    1. Hallek M., Shanafelt T. D., Eichhorst B. Chronic lymphocytic leukaemia. The Lancet . 2018;391(10129):1524–1537. doi: 10.1016/S0140-6736(18)30422-7. - DOI - PubMed
    1. Rozman C., Montserrat E. Chronic lymphocytic leukemia. New England Journal of Medicine . 1995;333(16):1052–1057. doi: 10.1056/NEJM199510193331606. - DOI - PubMed
    1. Lan Q., Au W. Y., Chanock S., et al. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. European Journal of Haematology . 2010;85(6):492–495. doi: 10.1111/j.1600-0609.2010.01518.x. - DOI - PMC - PubMed
    1. Gragert L., Fingerson S., Albrecht M., Maiers M., Kalaycio M., Hill B. T. Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations. Blood . 2014;124(17):2657–2665. doi: 10.1182/blood-2014-02-558767. - DOI - PMC - PubMed
    1. Hojjat-Farsangi M., Jeddi-Tehrani M., Amirzargar A. A., et al. Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia. Human Immunology . 2008;69(10):666–674. doi: 10.1016/j.humimm.2008.07.015. - DOI - PubMed