Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

Cassandra M J Wannan^{1

2}, Barnaby Nelson^{1

2}, Jean Addington³, Kelly Allott^{1

2}, Alan Anticevic^{4

5}, Celso Arango⁶, Justin T Baker⁷, Carrie E Bearden^{8

9}, Tashrif Billah¹⁰, Sylvain Bouix¹¹, Matthew R Broome^{12

13}, Kate Buccilli^{1

2}, Kristin S Cadenhead¹⁴, Monica E Calkins¹⁵, Tyrone D Cannon^{4

16}, Guillermo Cecci¹⁷, Eric Yu Hai Chen¹⁸, Kang Ik K Cho⁹, Jimmy Choi¹⁹, Scott R Clark^{20

21}, Michael J Coleman⁹, Philippe Conus²², Cheryl M Corcoran²³, Barbara A Cornblatt^{24

25}, Covadonga M Diaz-Caneja⁶, Dominic Dwyer^{1

2}, Bjørn H Ebdrup²⁶, Lauren M Ellman²⁷, Paolo Fusar-Poli^{28

29}, Liliana Galindo^{30

31}, Pablo A Gaspar³², Carla Gerber³³, Louise Birkedal Glenthøj^{34

35}, Robert Glynn^{36

37}, Michael P Harms³⁸, Leslie E Horton³⁹, René S Kahn²³, Joseph Kambeitz⁴⁰, Lana Kambeitz-Ilankovic⁴⁰, John M Kane^{24

25}, Tina Kapur⁴¹, Matcheri S Keshavan⁴², Sung-Wan Kim^{43

44}, Nikolaos Koutsouleris⁴⁵, Marek Kubicki^{9

46}, Jun Soo Kwon^{47

48}, Kerstin Langbein⁴⁹, Kathryn E Lewandowski⁷, Gregory A Light^{14

50}, Daniel Mamah⁵¹, Patricia J Marcy⁵², Daniel H Mathalon^{53

54}, Patrick D McGorry^{1

2}, Vijay A Mittal⁵⁵, Merete Nordentoft^{34

56}, Angela Nunez^{4

5}, Ofer Pasternak^{9

46}, Godfrey D Pearlson^{4

19}, Jesus Perez^{57

58}, Diana O Perkins⁵⁹, Albert R Powers 3rd^{4

5}, David R Roalf¹⁵, Fred W Sabb⁶⁰, Jason Schiffman⁶¹, Jai L Shah^{62

63}, Stefan Smesny⁴⁹, Jessica Spark^{1

2}, William S Stone⁴², Gregory P Strauss⁶⁴, Zailyn Tamayo^{4

5}, John Torous⁴³, Rachel Upthegrove^{11

65}, Mark Vangel⁶⁶, Swapna Verma⁶⁷, Jijun Wang⁶⁸, Inge Winter-van Rossum²⁵, Daniel H Wolf¹⁵, Phillip Wolff⁶⁹, Stephen J Wood^{1

2

70}, Alison R Yung^{71

72}, Carla Agurto¹⁷, Mario Alvarez-Jimenez^{1

2}, Paul Amminger^{1

2}, Marco Armando⁷³, Ameneh Asgari-Targhi⁴¹, John Cahill^{4

5}, Ricardo E Carrión^{24

25}, Eduardo Castro¹⁷, Suheyla Cetin-Karayumak⁹, M Mallar Chakravarty⁶³, Youngsun T Cho^{4

5}, David Cotter^{74

75}, Simon D'Alfonso⁷⁶, Michaela Ennis⁷, Shreyas Fadnavis⁹, Clara Fonteneau^{4

5}, Caroline Gao^{1

2}, Tina Gupta³⁹, Raquel E Gur¹⁵, Ruben C Gur¹⁵, Holly K Hamilton¹⁰, Gil D Hoftman^{8

9}, Grace R Jacobs¹⁰, Johanna Jarcho²⁷, Jie Lisa Ji^{4

5}, Christian G Kohler¹⁵, Paris Alexandros Lalousis^{12

77}, Suzie Lavoie^{1

2}, Martin Lepage⁶³, Einat Liebenthal⁷⁸, Josh Mervis²⁷, Vishnu Murty²⁷, Spero C Nicholas⁵¹, Lipeng Ning^{9

41}, Nora Penzel⁹, Russell Poldrack⁷⁹, Pablo Polosecki¹⁷, Danielle N Pratt⁵⁵, Rachel Rabin⁶², Habiballah Rahimi Eichi⁷, Yogesh Rathi^{10

41}, Avraham Reichenberg²³, Jenna Reinen¹⁷, Jack Rogers⁷⁷, Bernalyn Ruiz-Yu⁸, Isabelle Scott^{1

2}, Johanna Seitz-Holland¹⁰, Vinod H Srihari^{4

78}, Agrima Srivastava²³, Andrew Thompson^{1

2}, Bruce I Turetsky¹⁵, Barbara C Walsh^{4

5}, Thomas Whitford^{2

80}, Johanna T W Wigman⁸¹, Beier Yao⁷, Hok Pan Yuen^{1

2}, Uzair Ahmed², Andrew Jin Soo Byun^{82

83}, Yoonho Chung⁷, Kim Do^{84

85}, Larry Hendricks^{1

2}, Kevin Huynh^{1

2}, Clark Jeffries⁸⁶, Erlend Lane⁴², Carsten Langholm⁴², Eric Lin^{7

87

88}, Valentina Mantua⁸⁹, Gennarina Santorelli⁴³, Kosha Ruparel¹⁶, Eirini Zoupou¹⁶, Tatiana Adasme³², Lauren Addamo^{1

2}, Laura Adery^{8

9}, Munaza Ali^{4

5}, Andrea Auther²⁴, Samantha Aversa⁶², Seon-Hwa Baek^{43

44}, Kelly Bates⁵⁵, Alyssa Bathery⁸⁹, Johanna M M Bayer^{1

2}, Rebecca Beedham^{1

2}, Zarina Bilgrami⁶⁹, Sonia Birch^{1

2}, Ilaria Bonoldi^{28

29}, Owen Borders¹⁰, Renato Borgatti^{29

90}, Lisa Brown⁴¹, Alejandro Bruna³², Holly Carrington¹⁰, Rolando I Castillo-Passi^{32

91}, Justine Chen¹⁰, Nicholas Cheng^{1

2}, Ann Ee Ching^{1

2}, Chloe Clifford¹², Beau-Luke Colton^{1

2}, Pamela Contreras³², Sebastián Corral³², Stefano Damiani²⁹, Monica Done^{8

9}, Andrés Estradé⁹², Brandon Asika Etuka⁴, Melanie Formica^{1

2}, Rachel Furlan²⁷, Mia Geljic^{1

2}, Carmela Germano^{1

2}, Ruth Getachew^{1

2}, Mathias Goncalves⁷⁹, Anastasia Haidar¹⁰, Jessica Hartmann⁹³, Anna Jo⁴³, Omar John¹⁰, Sarah Kerins⁹², Melissa Kerr^{1

2}, Irena Kesselring⁸⁹, Honey Kim⁴³, Nicholas Kim¹⁰, Kyle Kinney²⁷, Marija Krcmar^{1

2}, Elana Kotler¹⁰, Melanie Lafanechere^{70

77}, Clarice Lee^{1

2}, Joshua Llerena^{1

2}, Christopher Markiewicz⁷⁹, Priya Matnejl⁵², Alejandro Maturana³², Aissata Mavambu¹², Rocío Mayol-Troncoso³², Amelia McDonnell²⁷, Alessia McGowan²³, Danielle McLaughlin⁵², Rebecca McIlhenny³⁹, Brittany McQueen^{1

2}, Yohannes Mebrahtu^{1

2}, Martina Mensi^{29

90}, Christy Lai Ming Hui¹⁸, Yi Nam Suen¹⁸, Stephanie Ming Yin Wong¹⁸, Neal Morrell^{1

2}, Mariam Omar^{1

2}, Alice Partridge^{1

2}, Christina Phassouliotis^{1

2}, Anna Pichiecchio^{29

94}, Pierluigi Politi²⁹, Christian Porter³⁹, Umberto Provenzani²⁹, Nicholas Prunier¹⁰, Jasmine Raj⁵⁵, Susan Ray⁵², Victoria Rayner^{1

2}, Manuel Reyes^{32

91}, Kate Reynolds^{1

2}, Sage Rush⁸⁹, Cesar Salinas³², Jashmina Shetty^{1

2}, Callum Snowball^{1

2}, Sophie Tod^{1

2}, Gabriel Turra-Fariña³², Daniela Valle³², Simone Veale¹⁰, Sarah Whitson^{1

2}, Alana Wickham¹⁰, Sarah Youn^{1

2}, Francisco Zamorano^{95

96}, Elissa Zavaglia⁶², Jamie Zinberg^{8

9}, Scott W Woods^{4

5}, Martha E Shenton^{10

41

46}

Affiliations

¹ Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
² Orygen, Parkville, VIC, Australia.
³ Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
⁴ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
⁵ Connecticut Mental Health Center, New Haven, CT, USA.
⁶ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.
⁷ Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
⁸ Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
⁹ Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
¹⁰ Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Software Engineering and Information Technology, École de technologie supérieure, Montréal, Canada.
¹² School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
¹³ Early Intervention for Psychosis Services, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
¹⁴ Department of Psychiatry, University of California, San Diego, CA, USA.
¹⁵ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁶ Department of Psychology, Yale University, New Haven, CT, USA.
¹⁷ IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
¹⁸ Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
¹⁹ Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA.
²⁰ Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
²¹ Basil Hetzel Institute, Woodville, SA, Australia.
²² General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
²³ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
²⁴ Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
²⁵ Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
²⁶ Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup, Copenhagen, Denmark.
²⁷ Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
²⁸ Department of Psychosis Studies, King's College London, London, UK.
²⁹ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
³⁰ Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
³¹ Department of Psychiatry, University of Cambridge, Cambridge, UK.
³² Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
³³ Behavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA.
³⁴ Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark.
³⁵ Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
³⁶ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³⁷ Department of Biostatistics, Harvard T.H. Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
³⁸ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
³⁹ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁴⁰ Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
⁴¹ Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
⁴² Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
⁴³ Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
⁴⁴ Mindlink, Gwangju Bukgu Mental Health Center, Gwangju, Korea.
⁴⁵ Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany.
⁴⁶ Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴⁷ Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
⁴⁸ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
⁴⁹ Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
⁵⁰ Veterans Affairs San Diego Health Care System, San Diego, CA, USA.
⁵¹ Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA.
⁵² Northwell Health, Glen Oaks, NY, USA.
⁵³ Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
⁵⁴ Mental Health Service 116D, Veterans Affairs San Francisco Health Care System, San Francisco, CA, USA.
⁵⁵ Department of Psychology, Northwestern University, Evanston, IL, USA.
⁵⁶ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁵⁷ CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
⁵⁸ Department of Medicine, Institute of Biomedical Research (IBSAL), Universidad de Salamanca, Salamanca, Spain.
⁵⁹ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁶⁰ Prevention Science Institute, University of Oregon, Eugene, OR, USA.
⁶¹ Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.
⁶² PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
⁶³ Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
⁶⁴ Department of Psychology, University of Georgia, Athens, GA, USA.
⁶⁵ Birmingham Womens and Childrens, NHS Foundation Trust, Birmingham, UK.
⁶⁶ Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁶⁷ Department of Psychosis, Institute of Mental Health, Singapore.
⁶⁸ Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁶⁹ Department of Psychology, Emory University, Atlanta, GA, USA.
⁷⁰ School of Psychology, University of Birmingham, Edgbaston, UK.
⁷¹ Institute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.
⁷² School of Health Sciences, University of Manchester, Manchester, UK.
⁷³ Youth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne, Lausanne, Switzerland.
⁷⁴ Department Psychiatry, Beaumont Hospital, Dublin 9, Ireland.
⁷⁵ Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
⁷⁶ School of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia.
⁷⁷ Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK.
⁷⁸ Program for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA.
⁷⁹ Department of Psychology, Stanford University, Stanford, CA, USA.
⁸⁰ School of Psychology, University of New South Wales (UNSW), Kensington, NSW, Australia.
⁸¹ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen, Netherlands.
⁸² Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
⁸³ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
⁸⁴ Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland.
⁸⁵ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, UK.
⁸⁶ Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
⁸⁷ Medical Informatics Fellowship, Veteran Affairs Boston Healthcare System, Boston, MA, USA.
⁸⁸ Food and Drug Administration, Silver Spring, MD, USA.
⁸⁹ Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
⁹⁰ IRCCS Mondino Foundation, Pavia, Italy.
⁹¹ Department of Neurology and Psychiatry, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
⁹² Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK.
⁹³ Department of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy, Mannheim, Germany.
⁹⁴ Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy.
⁹⁵ Unidad de imágenes cuantitativas avanzadas, departamento de imágenes, clínica alemana, universidad del Desarrollo, Santiago, Chile.
⁹⁶ Facultad de ciencias para el cuidado de la salud, Universidad San Sebastián, Campus Los Leones, Santiago, Chile.

PMID: 38451304
PMCID: PMC11059785
DOI: 10.1093/schbul/sbae011

Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

Cassandra M J Wannan et al. Schizophr Bull. 2024.

. 2024 Apr 30;50(3):496-512.

doi: 10.1093/schbul/sbae011.

Authors

Affiliations

¹ Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
² Orygen, Parkville, VIC, Australia.
³ Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
⁴ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
⁵ Connecticut Mental Health Center, New Haven, CT, USA.
⁶ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain.
⁷ Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA.
⁸ Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
⁹ Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
¹⁰ Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
¹¹ Department of Software Engineering and Information Technology, École de technologie supérieure, Montréal, Canada.
¹² School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK.
¹³ Early Intervention for Psychosis Services, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
¹⁴ Department of Psychiatry, University of California, San Diego, CA, USA.
¹⁵ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁶ Department of Psychology, Yale University, New Haven, CT, USA.
¹⁷ IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
¹⁸ Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong.
¹⁹ Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA.
²⁰ Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
²¹ Basil Hetzel Institute, Woodville, SA, Australia.
²² General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
²³ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
²⁴ Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
²⁵ Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
²⁶ Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup, Copenhagen, Denmark.
²⁷ Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
²⁸ Department of Psychosis Studies, King's College London, London, UK.
²⁹ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
³⁰ Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
³¹ Department of Psychiatry, University of Cambridge, Cambridge, UK.
³² Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile.
³³ Behavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA.
³⁴ Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark.
³⁵ Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
³⁶ Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³⁷ Department of Biostatistics, Harvard T.H. Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
³⁸ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
³⁹ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁴⁰ Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
⁴¹ Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
⁴² Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
⁴³ Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
⁴⁴ Mindlink, Gwangju Bukgu Mental Health Center, Gwangju, Korea.
⁴⁵ Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany.
⁴⁶ Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴⁷ Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
⁴⁸ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
⁴⁹ Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
⁵⁰ Veterans Affairs San Diego Health Care System, San Diego, CA, USA.
⁵¹ Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA.
⁵² Northwell Health, Glen Oaks, NY, USA.
⁵³ Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
⁵⁴ Mental Health Service 116D, Veterans Affairs San Francisco Health Care System, San Francisco, CA, USA.
⁵⁵ Department of Psychology, Northwestern University, Evanston, IL, USA.
⁵⁶ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁵⁷ CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
⁵⁸ Department of Medicine, Institute of Biomedical Research (IBSAL), Universidad de Salamanca, Salamanca, Spain.
⁵⁹ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁶⁰ Prevention Science Institute, University of Oregon, Eugene, OR, USA.
⁶¹ Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.
⁶² PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada.
⁶³ Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
⁶⁴ Department of Psychology, University of Georgia, Athens, GA, USA.
⁶⁵ Birmingham Womens and Childrens, NHS Foundation Trust, Birmingham, UK.
⁶⁶ Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁶⁷ Department of Psychosis, Institute of Mental Health, Singapore.
⁶⁸ Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁶⁹ Department of Psychology, Emory University, Atlanta, GA, USA.
⁷⁰ School of Psychology, University of Birmingham, Edgbaston, UK.
⁷¹ Institute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.
⁷² School of Health Sciences, University of Manchester, Manchester, UK.
⁷³ Youth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne, Lausanne, Switzerland.
⁷⁴ Department Psychiatry, Beaumont Hospital, Dublin 9, Ireland.
⁷⁵ Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
⁷⁶ School of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia.
⁷⁷ Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK.
⁷⁸ Program for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA.
⁷⁹ Department of Psychology, Stanford University, Stanford, CA, USA.
⁸⁰ School of Psychology, University of New South Wales (UNSW), Kensington, NSW, Australia.
⁸¹ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen, Netherlands.
⁸² Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
⁸³ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
⁸⁴ Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland.
⁸⁵ Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, UK.
⁸⁶ Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
⁸⁷ Medical Informatics Fellowship, Veteran Affairs Boston Healthcare System, Boston, MA, USA.
⁸⁸ Food and Drug Administration, Silver Spring, MD, USA.
⁸⁹ Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA.
⁹⁰ IRCCS Mondino Foundation, Pavia, Italy.
⁹¹ Department of Neurology and Psychiatry, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
⁹² Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK.
⁹³ Department of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy, Mannheim, Germany.
⁹⁴ Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy.
⁹⁵ Unidad de imágenes cuantitativas avanzadas, departamento de imágenes, clínica alemana, universidad del Desarrollo, Santiago, Chile.
⁹⁶ Facultad de ciencias para el cuidado de la salud, Universidad San Sebastián, Campus Los Leones, Santiago, Chile.

PMID: 38451304
PMCID: PMC11059785
DOI: 10.1093/schbul/sbae011

Abstract

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

Keywords: clinical high risk; consortium; early detection; prediction; prevention; psychosis.

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Figures

**Fig. 1.**
Accelerating Medicines Partnership Schizophrenia research networks and study sites.

**Fig. 2.**
Overview of the data flow from acquisition to National Institute of Mental Health (NIMH) Data Archive (NDA) curated releases.

See this image and copyright information in PMC

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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

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