Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug;29(8):2568-2570.
doi: 10.1038/s41380-024-02497-6. Epub 2024 Mar 7.

Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder

Lauren Clarke  1 , Neil Gesundheit  2 , Elliott H Sherr  3 , Antonio Y Hardan  1 , Karen J Parker  4   5
Affiliations

Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder

Lauren Clarke et al. Mol Psychiatry. 2024 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

LC, NG, and EHS have no interests to declare. AYH declares consulting fees from Quadrant Bio, IAMA therapeutics, and Beaming Health. AYH and KJP are receiving Vasostrict from Endo International free of charge for use in an investigator-initiated, NIH-funded phase IIb clinical trial that is evaluating the safety and efficacy of vasopressin treatment to improve social abilities in children with ASD. The Board of Trustees of the Leland Stanford Junior University has filed patent applications related to data reviewed herein: PCT/US2019/019029 (“Methods for diagnosing and determining severity of an autism spectrum disorder”) and PCT/US2019/041250 (“Intranasal Vasopressin Treatment for Social Deficits in Children with Autism”). These patents have not been granted, nor licensed, and no author is receiving financial compensation at this time.

References

    1. Rigney N, de Vries GJ, Petrulis A, Young LJ. Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities. Endocrinology. 2022;163:bqac111. - PMC - PubMed
    1. Caldwell HK, Lee HJ, Macbeth AH, Young WS 3rd. Vasopressin: behavioral roles of an “original” neuropeptide. Prog Neurobiol. 2008;84:1–24. - PMC - PubMed
    1. Insel TR, O’Brien DJ, Leckman JF. Oxytocin, vasopressin, and autism: is there a connection? Biol Psychiatry. 1999;45:145–57. - PubMed
    1. Parker KJ, Garner JP, Oztan O, Tarara ER, Li J, Sclafani V, et al. Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates. Sci Transl Med. 2018;10:eaam9100. - PMC - PubMed
    1. Oztan O, Garner JP, Constantino JN, Parker KJ. Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder. Proc Natl Acad Sci USA. 2020;117:10609–13. - PMC - PubMed