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Review
. 2024 Feb 26;16(2):126-136.
doi: 10.4252/wjsc.v16.i2.126.

Recent progress in hair follicle stem cell markers and their regulatory roles

Yi-Zhan Xing  1 , Hai-Ying Guo  1 , Fei Xiang  2 , Yu-Hong Li  3
Affiliations
Review

Recent progress in hair follicle stem cell markers and their regulatory roles

Yi-Zhan Xing et al. World J Stem Cells. .

Abstract

Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

Keywords: Bulge; Hair follicle stem cells; Marker; Secondary hair germ; Single-cell RNA-sequencing.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Hair follicle stem cells and the hair cycle. Telogen: The length of the hair follicle (HF) is the shortest. HF stem cells (HFSCs) remain quiescent until dermal papilla (DP) releases a new round of stimulations, which activate the hair germ cells at first, then HFSCs. Anagen: The activated HFSCs proliferate and differentiate, forming the outer root sheath and matrix via down growth. After that, the inner root sheath and hair shaft are formed from the matrix. Catagen: The cells in the matrix undergo apoptosis and form an epithelial strand, which retracts the DP. The HF shrinks gradually until entering the next telogen. HS: Hair shaft; SG: Sebaceous gland; HG: Hair germ; DP: Dermal papilla; IRS: Inner root sheath; ORS: Outer root sheath.
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