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. 2024 Jan 7;12(3):2104-2114.
doi: 10.1002/fsn3.3911. eCollection 2024 Mar.

Dietary therapy of the herbal porridge improves the symptoms of functional dyspepsia: A randomized, double-blind, placebo-controlled, clinical trial

Xin Wang  1   2   3   4 , Meng-Ao Liu  1   2   5 , Jia He  1   2   3   4 , Wen-Zhi Zhao  3   4   6 , Yi-Xuan Wang  3   4   6 , Liu-Qing Yang  3   4   6 , Tian-Yuan Wang  7 , Han-Ping Shi  1   2   3   4   6 , Ben-Qiang Rao  1   2   3   4
Affiliations

Dietary therapy of the herbal porridge improves the symptoms of functional dyspepsia: A randomized, double-blind, placebo-controlled, clinical trial

Xin Wang et al. Food Sci Nutr. .

Abstract

This study (ISRCTN17174559) aimed to explore the efficacy and safety of a kind of herbal porridge (Hou Gu Mi Xi) on the clinical symptoms of functional dyspepsia (FD). This was a single-center, single-dose, prospective, double-blind, randomized controlled trial involving 64 participants with FD (35 cases and 29 controls) for 2 months of intervention and 1 month of follow-up. The 7-point Global Overall Symptom Scale (GOSS), 36-Item Short Form Survey (SF-36), and other indicators were assessed at baseline (day 0), at days 15, 30, and 60 of treatment, and at follow-up 1 month after the end of the intervention. Many participants with FD achieved remission of their epigastric symptoms at follow-up on the 90th day after treatment with herbal porridge compared to the placebo group (45.71% vs. 20.69%, p = .036). Furthermore, herbal porridge appeared to be effective in improving the quality of life of participants with FD, which was reflected in the rising SF-36 scores for physical role, bodily pain, emotional role, and mental health. Although adverse events were reported, there was no overall difference in the number of adverse events between the two groups (p = .578). Herbal porridge is another effective and safe method for improving the symptoms and quality of life in patients with FD.

Keywords: dietary therapy; epigastric symptoms; functional dyspepsia; herbal porridge; randomized controlled trial; traditional Chinese medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram illustrating the number of participants in each group throughout the study.
FIGURE 2
FIGURE 2
Upper gastrointestinal symptoms in 64 participants with FD at baseline scored on the 7‐Point Global Overall Symptom Scale (GOSS).
FIGURE 3
FIGURE 3
The proportion of participants with improvement of epigastric symptoms at 15, 30, and 60 days of intervention and 90 days of follow‐up. Symptoms were scored using the GOSS scale, and the improvement of symptoms was defined as a ≥1 point reduction in GOSS score, compared with baseline (day 0), *p < .05, herbal porridge versus placebo; a marked improvement in symptoms was defined as a ≥2 point reduction in GOSS score, compared with baseline (day 0). #Number of cases with marked improvement in symptoms.
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