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. 2023 Dec 7;12(3):1749-1767.
doi: 10.1002/fsn3.3867. eCollection 2024 Mar.

Unveiling the pharmacological potential of Coelogyne suaveolens: An investigation of its diverse pharmacological activities by in vivo and computational studies

Taslima Akter Eva  1 , Husnum Mamurat  1 , Md Habibul Hasan Rahat  1 , S M Moazzem Hossen  1
Affiliations

Unveiling the pharmacological potential of Coelogyne suaveolens: An investigation of its diverse pharmacological activities by in vivo and computational studies

Taslima Akter Eva et al. Food Sci Nutr. .

Abstract

The medicinal potential of Coelogyne suaveolens, a traditional medicinal plant, was investigated through in vivo and molecular docking studies. The ethyl acetate fraction of the plant's acetonic extract was subjected to various bioactivity tests to assess its analgesic, anxiolytic, and sedative effects on Swiss albino mice. Furthermore, we used GCMS to identify the bioactive chemicals in the extract's ethyl acetate fraction. The root and bulb extracts demonstrated significant analgesic activity in acetic acid-induced writhing, hot plate, and tail immersion tests in a dose-dependent manner when compared to the control. Again, the extract exhibited moderate anxiolytic activity in the elevated plus maze test at a dosage of 400 mg/kg body weight, while the root extract showed significant anxiolytic activity in the hole board test at the same dosage. Significant sedative activity was observed in the hole cross, open field, and rotarod tests at a dosage of 400 mg/kg. According to molecular docking studies, the extract has the potential to serve as an analgesic medication by reducing the enzymatic activity of cyclooxygenases 1 and 2. Overall, the findings suggest that C. suaveolens has substantial therapeutic potential for the development of novel treatments for pain, anxiety, and sleep disorders.

Keywords: Coelogyne suaveolens; GCMS; analgesic; anxiolytic; computational work; sedative activity.

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Conflict of interest statement

The authors state that the publication of this article does not present any conflicts of interest for them.

Figures

FIGURE 1
FIGURE 1
Coelogyne suaveolens ethyl acetate fraction's GC–MS chromatogram (Bulb).
FIGURE 2
FIGURE 2
Coelogyne suaveolens ethyl acetate fraction's GC–MS chromatogram (Root).
FIGURE 3a
FIGURE 3a
Molecular docking interaction of compounds against Cyclooxygenase‐1 (PDB ID: 5wbe): (a1) 1,6‐Octadien‐3‐ol,3,7‐dimethyl‐, (a2) Bicyclo[3.1.1]heptan‐3‐one,2,6,6‐trimethyl‐, (1.alpha.,2.beta.,5.alpha.)‐, (a3) Isopulegol, (a4) 3,6‐Dimethyl‐2,3,3a,4,5,7a‐hexahydrobenzofuran, (a5) Geranyl Acetate, (a6) 9,12‐Octadecadienoic acid (Z,Z)‐, and (a7) Alpha Linolenic Acid.
FIGURE 3b
FIGURE 3b
Molecular docking interaction of compounds against Cyclooxygenase‐2 (PDB ID: 5ikq): (b1) 1,6‐Octadien‐3‐ol,3,7‐dimethyl‐, (b2) Bicyclo[3.1.1]heptan‐3‐one,2,6,6‐trimethyl‐, (1.alpha.,2.beta.,5.alpha.)‐, (b3) Isopulegol, (b4) 3,6‐Dimethyl‐2,3,3a,4,5,7a‐hexahydrobenzofuran, (b5) Geranyl Acetate, (b6) 9,12‐Octadecadienoic acid (Z,Z)‐, and (b7) Alpha Linolenic Acid.
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References

    1. Afrin, S. R. , Islam, M. R. , Khanam, B. H. , Proma, N. M. , Didari, S. S. , Jannat, S. W. , & Hossain, M. K. (2021). Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): A promising ethnomedicinal plant. Future Journal of Pharmaceutical Sciences, 7(1), 1–13.
    1. Akindele, A. J. , Ibe, I. F. , & Adeyemi, O. O. (2011). Analgesic and antipyretic activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) extract. African Journal of Traditional, Complementary, and Alternative Medicines, 9(1), 25–35. 10.4314/ajtcam.v9i1.4 - DOI - PMC - PubMed
    1. Al‐Nuri, M. , Abu‐Reidah, I. M. , Alhajeh, A. A. , Omar, G. , Adwan, G. , & Warad, I. (2022). GC–MS‐based metabolites profiling, in vitro antioxidant, anticancer, and antimicrobial properties of different solvent extracts from the botanical parts of Micromeria fruticosa (Lamiaceae). Processes, 10(5), 1016.
    1. Arunkumar, G. , Anbarasan, B. , Murugavel, R. , Uthrapathi, S. , & Visweswaran, S. (2019). Evaluation of analgesic activity of Gandhaga Sarkkarai in Swiss Albino mice by Eddy's hot plate method. 10.20959/wjpr20201-16141 - DOI
    1. Bachhav, R. S. , Gulecha, V. S. , & Upasani, C. D. (2009). Analgesic and anti‐inflammatory activity of Argyreia speciosa root. Indian Journal of Pharmacology, 41(4), 158–161. 10.4103/0253-7613.56066 - DOI - PMC - PubMed

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