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. 2024 Feb 22:15:1341448.
doi: 10.3389/fpsyt.2024.1341448. eCollection 2024.

Anxiety and depression among cancer patients in Ethiopia: a systematic review and meta-analysis

Habtamu Geremew  1 , Samuel Abdisa  2 , Elyas Melaku Mazengia  3 , Werkneh Melkie Tilahun  3 , Aysheshim Belaineh Haimanot  3 , Tigabu Kidie Tesfie  4 , Anteneh Lamesgen Mneneh  3 , Muluye Gebrie Mengie  3 , Bekalu Endalew  3 , Molla Yigzaw Birhanu  3 , Lakew Asmare  5 , Mulat Belay Simegn  3
Affiliations

Anxiety and depression among cancer patients in Ethiopia: a systematic review and meta-analysis

Habtamu Geremew et al. Front Psychiatry. .

Abstract

Introduction: Anxiety and depression are among the common comorbidities of people diagnosed with cancer. However, despite the progress in therapeutic options and outcomes, mental health care and support have lagged behind for cancer patients. Estimating the extent and determinants of mental health disorders among cancer patients is crucial to alert concerned bodies for action. In view of this, we aimed to determine the pooled prevalence and determinants of anxiety and depression among cancer patients in Ethiopia.

Methods: Relevant literatures were searched on PubMed, African Journals Online, Hinari, Epistemonikos, Scopus, EMBASE, CINAHL, Cochrane Library, and Gray literature sources. Data were extracted into an Excel spreadsheet and analyzed using STATA 17 statistical software. The random effect model was used to summarize the pooled effect sizes with their respective 95% confidence intervals. The I2 statistics and Egger's regression test in conjunction with the funnel plot were utilized to evaluate heterogeneity and publication bias among included studies respectively.

Results: A total of 17 studies with 5,592 participants were considered in this review. The pooled prevalence of anxiety and depression among cancer patients in Ethiopia were 45.10% (95% CI: 36.74, 53.45) and 42.96% (95% CI: 34.98, 50.93), respectively. Primary and above education (OR= 0.76, 95% CI: 0.60, 0.97), poor social support (OR= 2.27, 95% CI: 1.29, 3.98), occupational status (OR= 0.59; 95% CI: 0.43, 0.82), advanced cancer stage (OR= 2.19, 95% CI: 1.38, 3.47), comorbid illness (OR= 1.67; 95% CI: 1.09, 2.58) and poor sleep quality (OR= 11.34, 95% CI: 6.47, 19.89) were significantly associated with depression. Whereas, advanced cancer stage (OR= 1.59, 95% CI: 1.15, 2.20) and poor sleep quality (OR= 12.56, 95% CI: 6.4 1, 24.62) were the factors associated with anxiety.

Conclusion: This meta-analysis indicated that a substantial proportion of cancer patients suffer from anxiety and depression in Ethiopia. Educational status, occupational status, social support, cancer stage, comorbid illness and sleep quality were significantly associated with depression. Whereas, anxiety was predicted by cancer stage and sleep quality. Thus, the provision of comprehensive mental health support as a constituent of chronic cancer care is crucial to mitigate the impact and occurrence of anxiety and depression among cancer patients. Besides, families and the community should strengthen social support for cancer patients.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023468621.

Keywords: Ethiopia; anxiety; cancer patients; depression; prevalence.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow chart for articles screened and included.
Figure 2
Figure 2
Forest plot for prevalence of anxiety among cancer patients in Ethiopia.
Figure 3
Figure 3
Funnel plot, evaluating existence of publication bias for prevalence of anxiety among cancer patients in Ethiopia.
Figure 4
Figure 4
Forest plot for prevalence of depression among cancer patients in Ethiopia.
Figure 5
Figure 5
Funnel plot, evaluating the existence of publication bias for prevalence of depression among cancer patients in Ethiopia.
Figure 6
Figure 6
Sensitivity analysis for prevalence of anxiety among cancer patients in Ethiopia.
Figure 7
Figure 7
Sensitivity analysis for prevalence of depression among cancer patients in Ethiopia.
See this image and copyright information in PMC

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