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Review
. 2024 Feb 20;10(5):e26701.
doi: 10.1016/j.heliyon.2024.e26701. eCollection 2024 Mar 15.

Revisiting luteolin: An updated review on its anticancer potential

Abdur Rauf  1 , Polrat Wilairatana  2 , Payal B Joshi  3 , Zubair Ahmad  1 , Ahmed Olatunde  4 , Nabia Hafeez  5 , Hassan A Hemeg  6 , Mohammad S Mubarak  7
Affiliations
Review

Revisiting luteolin: An updated review on its anticancer potential

Abdur Rauf et al. Heliyon. .

Abstract

Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a natural flavone, present in significant amounts in various fruits and vegetables plays a key role as a chemopreventive agent in treating various types of cancer. By inducing apoptosis, initiating cell cycle arrest, and decreasing angiogenesis, metastasis, and cell proliferation, luteolin is used to treat cancer. Its anticancer properties are attributed to its capability to engage with multiple molecular targeted sites and modify various signaling pathways in tumor cells. Luteolin has been shown to slow the spread of cancer in breast, colorectal, lung, prostate, liver, skin, pancreatic, oral, and gastric cancer models. It exhibits antioxidant properties and can be given to patients receiving Doxorubicin (DOX) chemotherapy to prevent the development of unexpected adverse reactions in the lungs and hematopoietic system subjected to DOX. Furthermore, it could be an excellent candidate for synergistic studies to overcome drug resistance in cancer cells. Accordingly, this review covers the recent literature related to the use of luteolin against different types of cancer, along with the mechanisms of action. In addition, the review highlights luteolin as a complementary medicine for preventing and treating cancer.

Keywords: Anticancer; Luteolin; Metastasis; Phytochemical.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:No competing interests If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Chemical structure of luteolin and its glucosides.
Fig. 2
Fig. 2
Biosynthesis of dietary luteolin.
Fig. 3
Fig. 3
Luteolin against different forms of cancer.
See this image and copyright information in PMC

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