Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 3:3:1270374.
doi: 10.3389/fepid.2023.1270374. eCollection 2023.

Prevalence of asymptomatic cytomegalovirus (CMV) infection in newborns in northeast Florida

Rana Alissa  1 , Nizar Maraqa  1 , Patty D Williams  1 , Jennifer A Hipp  1 , Sfurti Nath  1 , Nicole S Torres  2 , Tiffany Lee  1 , Amr Matoq  1 , Mobeen Rathore  1
Affiliations

Prevalence of asymptomatic cytomegalovirus (CMV) infection in newborns in northeast Florida

Rana Alissa et al. Front Epidemiol. .

Abstract

Background: Congenital cytomegalovirus (CMV) infection is the leading cause of hearing loss and neurocognitive delay among children. Affected infants may be asymptomatic at birth and even pass their universal hearing screen. Early identification of CMV-infected infants will allow earlier detection, evaluation and management. The prevalence of congenital CMV infection in the developed world varies geographically from 0.6% to 0.7% of all deliveries and certain regions are at higher risk. The prevalence of congenital CMV is unknown for our region.

Aim: The purpose of this study was to determine the prevalence of CMV infection among the neonatal population at an urban, tertiary hospital in northeast Florida which serves a large population of patients with low socioeconomic status to assess if universal screening program for congenital asymptomatic CMV infection can be determined.

Methods: The study was submitted and approved by our Institutional Review Board. We tested the urine for CMV infection in 100 asymptomatic newborns (>32 weeks gestational age and >1,750 g weight at the time of delivery) delivered between June 2016 and July 2017.

Results: Urine CMV was tested on 100 infants. One infant had a positive urine NAAT for CMV, making the prevalence of congenital CMV infection among asymptomatic newborns in our hospitals' population 1%.

Conclusion: CMV prevalence in our setting of an urban, tertiary hospital is relatively consistent with the national average of all congenital CMV infections. A policy of universal screening for congenital CMV may be necessary.

Keywords: congenital CMV; early intervention; saliva testing; sensorineural hearing loss (SNHL); universal screening; urine testing.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Under-18 poverty rate in the zip codes which represent our hospital's population.
See this image and copyright information in PMC

References

    1. Morton CC, Nance WE. Newborn hearing screening–a silent revolution. N Engl J Med. (2006) 354(20):2151–64. 10.1056/NEJMra050700 - DOI - PubMed
    1. Fowler KB, McCollister FP, Dahle AJ, Boppana S, Britt WJ, Pass RF. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr. (1997) 130(4):624–30. 10.1016/s0022-3476(97)70248-8 - DOI - PubMed
    1. Fowler KB, Dahle AJ, Boppana SB, Pass RF. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed? J Pediatr. (1999) 135(1):60–4. 10.1016/s0022-3476(99)70328-8 - DOI - PubMed
    1. Fowler KB, Boppana SB. Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol. (2006) 35(2):226–31. 10.1016/j.jcv.2005.09.016 - DOI - PubMed
    1. Cheeran MC, Lokensgard JR, Schleiss MR. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev. (2009) 22(1):99–126. 10.1128/CMR.00023-08 - DOI - PMC - PubMed

LinkOut - more resources