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. 2024 Sep;47(9):2313-2323.
doi: 10.1007/s40618-024-02324-3. Epub 2024 Mar 8.

Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study

A Valer-Martinez  1   2 , C Sayon-Orea  3   4   5   6 , J A Martinez  7   8 , F J Basterra-Gortari  1   9   10 , M A Martinez-Gonzalez  1   11   9   12 , M Bes-Rastrollo  1   11   9
Affiliations

Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study

A Valer-Martinez et al. J Endocrinol Invest. 2024 Sep.

Abstract

Purpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population.

Methods: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings.

Results: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26-0.88; p for trend = 0.032).

Conclusion: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.

Keywords: Predicted vitamin D; Prospective cohort; SUN project; Type 2 diabetes.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study, collection, analysis and interpretation of the data; they did not intervene either in the writing process nor the decision to publish the outcomes.

Figures

Fig. 1
Fig. 1
Flowchart of participants included in the present analyses. aWillett’s energy limits (< 800 kcal/d or > 4000 kcal/d in men and < 500 kcal/d or > 3500 kcal/d in women)
Fig. 2
Fig. 2
Restricted cubic splines dose–response pattern: adjusted hazard ratios (HR)* and 95% confidence intervals (CI) for the development of T2D according to predicted serum vitamin D. *Adjusted for sex, age, marital status, smoking status (current, former or never smoker), smoking pack-years, weight change, years of university, TV hours/day, family history of T2D, physical activity (MET-h/week), Trichopoulou’s 9-point score/Mediterranean dietary pattern, energy intake (kcal/day), sugar-sweetened beverage consumption (servings/day), snacking, following a special diet, prevalent hypertension, prevalent cancer, prevalent hypercholesterolemia, prevalent hypertriglyceridemia and obesity (>= 30 kg/m2 yes, no)
See this image and copyright information in PMC

References

    1. Stumvoll M, Goldstein BJ, van Haeften T (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346 10.1016/S0140-6736(05)61032-X - DOI - PubMed
    1. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109–119 10.1016/j.diabres.2021.109119 - DOI - PMC - PubMed
    1. Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S et al (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103(4):1033–1044 10.3945/ajcn.115.120873 - DOI - PMC - PubMed
    1. Schleicher RL, Sternberg MR, Looker AC, Yetley EA, Lacher DA, Sempos CT et al (2016) National estimates of serum total 25-hydroxyvitamin D and metabolite concentrations measured by liquid chromatography-tandem mass spectrometry in the US population during 2007–2010. J Nutr 146(5):1051–1061 10.3945/jn.115.227728 - DOI - PMC - PubMed
    1. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A et al (2020) Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr 74:1498–1513 10.1038/s41430-020-0558-y - DOI - PMC - PubMed

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