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Review
. 2024 Mar 8;36(1):63.
doi: 10.1007/s40520-023-02679-2.

Medication review and deprescribing in different healthcare settings: a position statement from an Italian scientific consortium

Massimo Carollo  1 , Virginia Boccardi  2 , Salvatore Crisafulli  1 , Valeria Conti  3 , Paola Gnerre  4 , Simonetta Miozzo  5 , Emanuela Omodeo Salè  6   7 , Fabio Pieraccini  8 , Mauro Zamboni  9 , Alessandra Marengoni  10 , Graziano Onder  11   12 , Gianluca Trifirò  13 ; Italian Scientific Consortium on medication review, deprescribing
Collaborators, Affiliations
Review

Medication review and deprescribing in different healthcare settings: a position statement from an Italian scientific consortium

Massimo Carollo et al. Aging Clin Exp Res. .

Abstract

Recent medical advancements have increased life expectancy, leading to a surge in patients affected by multiple chronic diseases and consequent polypharmacy, especially among older adults. This scenario increases the risk of drug interactions and adverse drug reactions, highlighting the need for medication review and deprescribing to reduce inappropriate medications and optimize therapeutic regimens, with the ultimate goal to improving patients' health and quality of life. This position statement from the Italian Scientific Consortium on medication review and deprescribing aims to describe key elements, strategies, tools, timing, and healthcare professionals to be involved, for the implementation of medication review and deprescribing in different healthcare settings (i.e., primary care, hospital, long-term care facilities, and palliative care). Challenges and potential solutions for the implementation of medication review and deprescribing are also discussed.

Keywords: Deprescribing; Frailty; Medication review; Multimorbidity; Patient-centered care; Polypharmacy.

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Conflict of interest statement

GT has served in the last 3 years on advisory boards/seminars funded by Sanofi, Eli Lilly, AstraZeneca, Abbvie, Novo Nordisk, Gilead, and Amgen; he is also a scientific coordinator of the academic spin-off “INSPIRE srl”, which has received funding for conducting observational studies from several pharmaceutical companies. None of these listed activities is related to the topic of the article. The other authors have no competing interests to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Main activities of a Medication Review and Deprescribing Service
See this image and copyright information in PMC

References

    1. Onder G, Vetrano DL, Palmer K, et al. Italian guidelines on management of persons with multimorbidity and polypharmacy. Aging Clin Exp Res. 2022;34:989–996. doi: 10.1007/s40520-022-02094-z. - DOI - PMC - PubMed
    1. Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17:230. doi: 10.1186/s12877-017-0621-2. - DOI - PMC - PubMed
    1. Osservatorio Nazionale sull’Impiego dei Medicinali (OsMed). L’uso dei farmaci in Italia. Agenzia Italiana del Farmaco. https://www.aifa.gov.it/rapporti-osmed. Accessed 14 Nov 2023
    1. Chan SL, Ang X, Sani LL, et al. Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study. Br J Clin Pharmacol. 2016;82:1636–1646. doi: 10.1111/bcp.13081. - DOI - PMC - PubMed
    1. Motter FR, Fritzen JS, Hilmer SN, et al. Potentially inappropriate medication in the elderly: a systematic review of validated explicit criteria. Eur J Clin Pharmacol. 2018;74:679–700. doi: 10.1007/s00228-018-2446-0. - DOI - PubMed

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