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. 2024 Mar 8;22(1):252.
doi: 10.1186/s12967-024-05061-6.

Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study

Bingquan Xiong #  1 , Yufan Wang #  2 , Juan He #  1 , Lisha Wang #  1 , Rui He  3 , Min Zhu  4 , Jiaxing Wang  5 , Yingrui Li  1 , Bin Liu  1 , Kaihu Xiao  1 , Qiang She  6
Affiliations

Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study

Bingquan Xiong et al. J Transl Med. .

Abstract

Background: Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria. However, the relationship of specific-domain PA and albuminuria remained obscure.

Methods: Albuminuria was defined as urinary albumin/creatinine ratio (ACR) > 30 mg/g. PA was self-reported by participants and classified into transportation-related PA (TPA), occupation-related PA (OPA), and leisure-time PA (LTPA). Weighted logistic regression was conducted to compute the odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic spline (RCS) was used to evaluate the dose-response of PA domains with the risk of albuminuria.

Results: A total of 6739 diabetic/prediabetic patients (mean age: 56.52 ± 0.29 years) were enrolled in our study, including 3181 (47.20%) females and 3558 (52.80%) males. Of them, 1578 (23.42%) were identified with albuminuria, and 5161(76.58%) were without albuminuria. Diabetic/prediabetic patients who adhered the PA guidelines for total PA had a 22% decreased risk of albuminuria (OR = 0.78, 95%CI 0.64-0.95), and those met the PA guidelines for LTPA had a 28% decreased of albuminuria (OR = 0.72, 95%CI 0.57-0.92). However, OPA and TPA were both not associated with decreased risk of albuminuria. RCS showed linear relationship between the risk of albuminuria with LTPA.

Conclusions: Meeting the PA guideline for LTPA, but not OPA and TPA, was inversely related to the risk of albuminuria among diabetic/prediabetic patients. Additionally, achieving more than 300 min/week of LTPA conferred the positive effects in reducing albuminuria among diabetic/prediabetic patients.

Keywords: Albuminuria; Diabetes; Lifestyle; Physical activity; Risk.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the study design
Fig. 2
Fig. 2
Multivariable OR for albuminuria among diabetic/prediabetic patients based on the amount of PA
Fig. 3
Fig. 3
Restricted cubic spline analysis (RCS) with multivariate-adjusted associations between PA domains and the risk of albuminuria among diabetic/prediabetic patients. a RCS analysis between total PA and albuminuria risk. b RCS analysis between LTPA and albuminuria risk. c RCS analysis between TPA and albuminuria risk. d RCS analysis between OPA and albuminuria risk
Fig. 4
Fig. 4
Subgroup analysis of the association of total PA and LTPA with albuminuria risk among diabetic/prediabetic patients
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