Neonatal skin dysbiosis to infantile atopic dermatitis: Mitigating effects of skin care

Reika Aoyama¹, Seitaro Nakagawa^{1

2

3}, Yoko Ichikawa⁴, Naohiro Inohara³, Yuriko Yamazaki^{1

5}, Tomoka Ito¹, Takashi Sugihira², Michihiro Kono⁶, Masashi Akiyama⁷, Hiroki Takahashi^{8

9}, Akiko Takaya^{8

9

10}, Fumitaka Ichikawa¹¹, Taiji Nakano¹², Seiko Tanaka¹³, Yutaka Koyano¹³, Manabu Fujimoto¹, Gabriel Núñez³, Naoki Shimojo¹⁴, Yuumi Nakamura^{1

5}

Affiliations

¹ Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
² Department of Cutaneous Immunology and Microbiology, Graduate School of Medicine, Osaka University, Osaka, Japan.
³ Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
⁴ Department of Pediatrics, Ichikawa Clinic, Fukushima, Japan.
⁵ Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
⁶ Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
⁷ Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁸ Medical Mycology Research Center, Chiba University, Chiba, Japan.
⁹ Plant Molecular Science Center, Chiba University, Chiba, Japan.
¹⁰ Department of Infection Control Science, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
¹¹ Department of Obstetrics and Gynecology, Ichikawa Clinic, Fukushima, Japan.
¹² Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
¹³ Natural Science Co., Ltd., Tokyo, Japan.
¹⁴ Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

Free article

Reika Aoyama et al. Allergy. 2024 Jun.

Free article

. 2024 Jun;79(6):1618-1622.

doi: 10.1111/all.16095. Epub 2024 Mar 9.

¹ Department of Dermatology, Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
² Department of Cutaneous Immunology and Microbiology, Graduate School of Medicine, Osaka University, Osaka, Japan.
³ Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
⁴ Department of Pediatrics, Ichikawa Clinic, Fukushima, Japan.
⁵ Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
⁶ Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
⁷ Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
⁸ Medical Mycology Research Center, Chiba University, Chiba, Japan.
⁹ Plant Molecular Science Center, Chiba University, Chiba, Japan.
¹⁰ Department of Infection Control Science, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
¹¹ Department of Obstetrics and Gynecology, Ichikawa Clinic, Fukushima, Japan.
¹² Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
¹³ Natural Science Co., Ltd., Tokyo, Japan.
¹⁴ Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

No abstract available

References

1. Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012;22(5):850‐859.
1. Nakamura Y, Takahashi H, Takaya A, et al. Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development. Sci Transl Med. 2020;12(551):eaay4068.
1. Dissanayake E, Tani Y, Nagai K, et al. Skin care and synbiotics for prevention of atopic dermatitis or food allergy in newborn infants: a 2 × 2 factorial, randomized, non‐treatment controlled trial. Int Arch Allergy Immunol. 2019;180(3):202‐211.
1. Tanabe H, Sakurai K, Kato T, et al. Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: a pilot study from the Chiba study of mother and child health birth cohort. World Allergy Organ J. 2019;12(10):100065.