Laparoscopic retroperitoneal lymphadenectomy for ovarian mixed germ cell tumor in a patient with situs inversus totalis; reporting the first case worldwide with literature review and in silico analysis

Abstract

Background: Situs inversus totalis (SIT) is a rare autosomal recessive inheritance at which the abdomino-thoracic organs are mirror-image transposed. Germ cell tumors originate from the primitive germ cell of the ovary and testis.

Case report presentation: A rare association between malignant ovarian mixed germ cell tumor and SIT was presented in a 32-years-old Egyptian female, successfully treated with laparoscopic total abdominal hysterectomy, right salpingo-oophorectomy, and retroperitoneal lymphadenectomy (laparoscopic retroperitoneal lymphadenectomy) of both sides. This case is considered the first of its kind worldwide.

Conclusion: SIT may be associated with malignant ovarian germ cell tumors. Surgical intervention could be done laparoscopically.

Keywords: Case report; Lymphadenectomy; Malignant ovarian germ cell tumors (MOGCT); Situs inversus totalis (SIT); in silico analysis.