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Review
. 2024 Mar 10;44(1):28.
doi: 10.1007/s10571-024-01461-w.

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases

Abdolkarim Talebi Taheri  1   2 , Zakieh Golshadi  3 , Hamidreza Zare  4 , Azam Alinaghipour  5 , Zahra Faghihi  6 , Ehsan Dadgostar  7   8 , Zeinab Tamtaji  9 , Michael Aschner  10 , Hamed Mirzaei  11 , Omid Reza Tamtaji  12   13 , Fatemeh Nabavizadeh  14   15
Affiliations
Review

The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer's and Parkinson's Diseases

Abdolkarim Talebi Taheri et al. Cell Mol Neurobiol. .

Abstract

Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding RNAs has been associated with inhibition or stimulation of autophagy. Decreased miR-124 led to decreased/increased autophagy in experimental model of Alzheimer and Parkinson diseases. Increased BACE1-AS showed enhanced autophagy in Alzheimer disease by targeting miR-214-3p, Beclin-1, LC3-I/LC3-II, p62, and ATG5. A significant increase in NEAT1led to stimulated autophagy in experimental model of PD by targeting PINK1, LC3-I, LC3-II, p62 and miR-374c-5p. In addition, increased BDNF-AS and SNHG1 decreased autophagy in MPTP-induced PD by targeting miR-125b-5p and miR-221/222, respectively. The upregulation of circNF1-419 and circSAMD4A resulted in an increased autophagy by regulating Dynamin-1 and miR-29c 3p, respectively. A detailed discussion of miRNAs, circRNAs, and lncRNAs in relation to their autophagy-related signaling pathways is presented in this study.

Keywords: Autophagy; Long non-coding (lnc) RNA; Neurodegenerative disorders; Non-coding RNAs; microRNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
A schematic representation of the autophagy pathway. This figure adapted from (Riebisch et al. 2021)
See this image and copyright information in PMC

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