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. 2024 Mar 12;37(4):347-352.
doi: 10.1515/jpem-2023-0565. Print 2024 Apr 25.

Investigating the connection among thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents affected by type 1 diabetes

Valeria Calcaterra  1   2 , Chiara Mameli  2   3 , Maddalena Macedoni  2 , Annalisa De Silvestri  4 , Laura Sgambetterra  2 , Federico Nosenzo  2 , Francesca Chiara Redaelli  2 , Agnese Petitti  2 , Alessandra Bosetti  2 , Gianvincenzo Zuccotti  2   3
Affiliations

Investigating the connection among thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents affected by type 1 diabetes

Valeria Calcaterra et al. J Pediatr Endocrinol Metab. .

Abstract

Objectives: A connection between thyroid hormones (THs) and diverse metabolic pathways has been reported. We evaluated thyroid function and tissue sensitivity to THs in children and adolescents with T1D in comparison to euthyroid controls. Additionally, we investigate whether a relationship exists between sensitivity indices and metabolic parameters.

Methods: A retrospective analysis was conducted on 80 pediatric patients diagnosed with T1D. Clinical parameters, TSH, FT3, FT4, and the presence of MS were documented. Additionally, indices of peripheral sensitivity (FT3/FT4 ratio) and central sensitivity (TSH index, TSHI; TSH T4 resistance index, TT4RI; TSH T3 resistance index, TT3RI) were assessed. Thirty healthy subjects were considered as controls.

Results: The overall prevalence of MS was 7.27 %, with MS identified in 8 out of 80 (10 %) T1D subjects; none of the controls manifested MS (p<0.01). No significant differences were observed in indexes of tissue sensitivity to THs between subjects with or without MS (all p>0.05). Correlations between THs and indexes of THs tissue sensitivity and metabolic parameters in controls and T1D patients were noted.

Conclusions: This study affirms a heightened prevalence of MS in children with T1D compared to controls and underscores the potential role of THs in maintaining metabolic equilibrium.

Keywords: adolescents; metabolic syndrome children; sensitivity to thyroid hormones; thyroid function; type 1 diabetes.

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References

    1. Kassi, E, Pervanidou, P, Kaltsas, G, Chrousos, G. Metabolic syndrome: definitions and controversies. BMC Med 2011;9:48. DOI https://doi.org/10.1186/1741-7015-9-48 - DOI
    1. Dilworth, L, Facey, A, Omoruyi, F. Diabetes mellitus and its metabolic complications: the role of adipose tissues. Int J Mol Sci 2021;22:7644. https://doi.org/10.3390/ijms22147644 - DOI
    1. He, J, Lai, Y, Yang, J, Yao, Y, Li, Y, Teng, W, et al.. The relationship between thyroid function and metabolic syndrome and its components: a cross-sectional study in a Chinese population. Front Endocrinol 2021;12:661160. https://doi.org/10.3389/fendo.2021.661160 - DOI
    1. Tropeano, A, Corica, D, Curatola, S, Li Pomi, A, Casto, C, Alibrandi, A, et al.. The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children. J Endocrinol Invest 2023;46:285–95. https://doi.org/10.1007/s40618-022-01899-z - DOI
    1. Waring, AC, Rodondi, N, Harrison, S, Kanaya, AM, Simonsick, EM, Miljkovic, I, et al.; Health, Ageing, and Body Composition (Health ABC) Study . Thyroid function and prevalent and incident metabolic syndrome in older adults: the health, ageing and body composition study. Clin Endocrinol 2012;76:911–8. https://doi.org/10.1111/j.1365-2265.2011.04328.x . - DOI

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