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Review
. 2024 Mar 5;17(3):100886.
doi: 10.1016/j.waojou.2024.100886. eCollection 2024 Mar.

Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group

Jorge F Maspero  1 , Wilma Anselmo-Lima  2 , David Bedoya  3 , Marcos Alejandro Jimenez Chobillón  4 , Javier Ospina  5 , Renato Roithmann  6 , Andrés Sadek Gonzalez  7 , Ricardo Silva Rueda  8
Affiliations
Review

Management of CRSwNP in Latin America: A multidisciplinary consensus from an expert working group

Jorge F Maspero et al. World Allergy Organ J. .

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly through type 2 inflammatory processes. Clinical management is challenging, and a multidisciplinary approach is preferred. Principal treatment approaches are the use of local/systemic corticosteroids and sinonasal surgery, although outcomes can be unsatisfactory. Recent availability of biological therapies targeting underlying inflammatory processes can offer effective treatment options in uncontrolled disease. Specialist guidelines greatly assist clinical decision-making, although as these are chiefly written from a global/international perspective, they may not wholly accommodate disease patterns and clinical practice at a regional level. An expert panel of specialists from Latin America was convened to develop regional guidance on the management of CRSwNP through a consensus approach. The present article presents the chief observations and recommendations which can provide guidance for clinicians in the Latin American region.

Keywords: Biologics; CRSwNP; Chronic rhinosinusitis with nasal polyposis; Type 2 inflammation.

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Conflict of interest statement

JFM has acted as a speaker, advisory board member, and/or investigator for Sanofi, AstraZeneca, Novartis, Inmunito, Uriach, GSK, Menarini and MSD. DB has attended advisory board and received sponsorship from Sanofi. AS has acted as an advisor for Sanofi. WA-L, MAJC, JO, RR and RSR have no direct or indirect conflict of interests to declare.

Figures

Fig. 1
Fig. 1
Treatment approach in CRSwNP. A step-wise approach is recommended. Abbreviations: CRSwNP, chronic rhinosinusitis with nasal polyps; ESS, endoscopic sinus surgery
Fig. 2
Fig. 2
Criteria for use of biologics and assessment of treatment response. Abbreviations: CRSwNP, chronic rhinosinusitis with nasal polyps; ESS, endoscopic sinus surgery; SNOT-22: Sino-nasal outcome test-22; UPSIT: University of Pennsylvania smell identification test
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