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Case Reports
. 2024 Mar 8;11(3):e01299.
doi: 10.14309/crj.0000000000001299. eCollection 2024 Mar.

A Rare Case of Cutaneous Gastric Adenocarcinoma With Signet Ring Cell Features

Alexander Garcia  1 , Arman Maqsudlu  1 , Ishita Dhawa  2 , Adib Chaaya  2
Affiliations
Case Reports

A Rare Case of Cutaneous Gastric Adenocarcinoma With Signet Ring Cell Features

Alexander Garcia et al. ACG Case Rep J. .

Erratum in

Abstract

Cutaneous metastatic disease from primary gastric cancer is quite scarce, often going unrecognized. In this case, the patient presented with an expanding rash that was biopsied, with findings concerning for metastatic adenocarcinoma from a suspected luminal upper gastrointestinal origin. Subsequent biopsies during an esophagogastroduodenoscopy confirmed poorly differentiated adenocarcinoma with signet ring cell features, most likely from an upper gastrointestinal primary (gastric vs gastroesophageal junction). We review this case to help providers identify signet cell type cutaneous metastases of gastric cancer quickly to improve patient outcomes.

Keywords: metastatic gastric adenocarcinoma; signet ring cells; skin cancer.

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Figures

Figure 1.
Figure 1.
Cutaneous manifestation of metastatic adenocarcinoma from upper gastrointestinal source (likely gastric).
Figure 2.
Figure 2.
Noncircumferential submucosal mass of the greater curvature of the stomach as seen on upper endoscopy.
Figure 3.
Figure 3.
Fungating circumferential mass of the gastric body as seen on upper endoscopy.
Figure 4.
Figure 4.
100× magnification, hematoxylin and eosin-stained biopsy of gastric mucosa.
Figure 5.
Figure 5.
200× magnification, hematoxylin and eosin-stained biopsy of gastric mucosa. Arrowheads highlight the tumor cells infiltrating in the lamina propria of the gastric mucosa.
See this image and copyright information in PMC

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