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Review
. 2024 Mar 3;10(5):e27480.
doi: 10.1016/j.heliyon.2024.e27480. eCollection 2024 Mar 15.

Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME)

Mahvash Sadeghi  1   2 , Sajad Dehnavi  3 , Moosa Sharifat  1 , Amir Mohammad Amiri  1   2 , Ali Khodadadi  1   4
Affiliations
Review

Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME)

Mahvash Sadeghi et al. Heliyon. .

Abstract

The tumor microenvironment (TME) with vital role in cancer progression is composed of various cells such as endothelial cells, immune cells, and mesenchymal stem cells. In particular, innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, neutrophils, innate lymphoid cells, γδT lymphocytes, and natural killer cells can either promote or suppress tumor progression when present in the TME. An increase in research on the cross-talk between the TME and innate immune cells will lead to new approaches for anti-tumoral therapeutic interventions. This review primarily focuses on the biology of innate immune cells and their main functions in the TME. In addition, it summarizes several innate immune-based immunotherapies that are currently tested in clinical trials.

Keywords: Anti-tumor treatment; Immunotherapy; Innate immune cells; Tumor microenvironment (TME).

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

Figures

Fig. 1
Fig. 1
Schematic presentation of pro-tumoral and anti-tumoral function of innate immune cells in the TME. Abbreviation: VEGF, vascular endothelial growth factor; MMPs, Matrix metalloproteinases; MPO, myeloperoxidase; NE, neutrophil elastase; PlGF, placental growth factor. ROS, reactive oxygen species; iNOS, inducible nitric oxide synthase; ADCC, antibody-dependent cellular cytotoxicity; Fasl, Fas ligand; TRAIL, TNF-related apoptosis-inducing ligand.
See this image and copyright information in PMC

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