Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network
- PMID: 38464465
- PMCID: PMC10917732
- DOI: 10.1007/s13755-023-00269-0
Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network
Abstract
Background: Radiomics-based morphological brain networks (radMBN) constructed from routinely acquired structural MRI (sMRI) data have gained attention in Alzheimer's disease (AD). However, the radMBN suffers from limited characterization of AD because sMRI only characterizes anatomical changes and is not a direct measure of neuronal pathology or brain activity.
Purpose: To establish a group sparse representation of the radMBN under a joint constraint of group-level white matter fiber connectivity and individual-level sMRI regional similarity (JCGS-radMBN).
Methods: Two publicly available datasets were adopted, including 120 subjects from ADNI with both T1-weighted image (T1WI) and diffusion MRI (dMRI) for JCGS-radMBN construction, 818 subjects from ADNI and 200 subjects solely with T1WI from AIBL for validation in early AD diagnosis. Specifically, the JCGS-radMBN was conducted by jointly estimating non-zero connections among subjects, with the regularization term constrained by group-level white matter fiber connectivity and individual-level sMRI regional similarity. Then, a triplet graph convolutional network was adopted for early AD diagnosis. The discriminative brain connections were identified using a two-sample t-test, and the neurobiological interpretation was validated by correlating the discriminative brain connections with cognitive scores.
Results: The JCGS-radMBN exhibited superior classification performance over five brain network construction methods. For the typical NC vs. AD classification, the JCGS-radMBN increased by 1-30% in accuracy over the alternatives on ADNI and AIBL. The discriminative brain connections exhibited a strong connectivity to hippocampus, parahippocampal gyrus, and basal ganglia, and had significant correlation with MMSE scores.
Conclusion: The proposed JCGS-radMBN facilitated the AD characterization of brain network established on routinely acquired imaging modality of sMRI.
Supplementary information: The online version of this article (10.1007/s13755-023-00269-0) contains supplementary material, which is available to authorized users.
Keywords: Alzheimer’s disease; Graph neural network; Magnetic resonance imaging; Radiomics.
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Conflict of interest statement
Conflict of interestThe authors have no potential conflicts of interest to disclose.
References
-
- Liu J, Li M, Pan Y, Lan W, Zheng R, Wu F-X, et al. Complex brain network analysis and its applications to brain disorders: a survey. Complexity. 2017;2017:8362741.
-
- Feng J, Zhang S-W, Chen L, Zuo C, AsDN Initiative. Detection of Alzheimer’s disease using features of brain region-of-interest-based individual network constructed with the sMRI image. Comput Med Imaging Graph. 2022;98:102057. - PubMed
LinkOut - more resources
Full Text Sources
