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Review
. 2024 Feb 23:15:1348852.
doi: 10.3389/fimmu.2024.1348852. eCollection 2024.

Opportunities and challenges for anti-CD47 antibodies in hematological malignancies

Yilan Xu  1 , Panruo Jiang  2 , Zhenyan Xu  1 , Haige Ye  1
Affiliations
Review

Opportunities and challenges for anti-CD47 antibodies in hematological malignancies

Yilan Xu et al. Front Immunol. .

Abstract

CD47 is a cell-surface ligand that is overexpressed in various malignancies and that binds to SIRPα on macrophages to promote tumor cell evasion of phagocytosis. Blocking the CD47-SIRPα axis can increase the phagocytosis of macrophages to exert antitumor effects. CD47-based immunotherapy is a current research focus. The combination of anti-CD47 antibodies with other drugs has shown encouraging response rates in patients with hematological tumors, but side effects also occur. Bispecific antibodies and SIRPα/Fc fusion proteins appear to balance the efficacy and safety of treatment. We review the latest clinical research advances and discuss the opportunities and challenges associated with CD47-based immunotherapy for hematological malignancies.

Keywords: anti-CD47 antibody; cd47; hematological malignancies; immunotherapy; magrolimab.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The mechanism of CD47-based immunotherapy. (A) CD47 expressed on tumor cells binds to SIRPα on macrophages to activate the “don’t eat me” signal to enable tumor cells to escape macrophage-mediated phagocytosis. (B) Anti-CD47 monoclonal antibody, anti-SIRPα antibody, recombinant SIRPα protein and bispecific antibody inhibit the CD47-SIRPα interaction, leading to macrophage phagocytosis of tumor cells.
See this image and copyright information in PMC

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