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. 2024 Mar 8;9(2):247.
doi: 10.1097/j.pbj.0000000000000247. eCollection 2024 Mar-Apr.

Prognostic impact of thrombocytosis in gastric cancer-A retrospective study

Bárbara Neto Castro  1 , Catarina Costa  1 , Daniel Martins  1 , Andreia Amado  1 , Mariana Santos  1 , Susana Graça  1 , Amélia Tavares  1 , António Ferreira  1 , Fernando Viveiros  1 , Sílvio Vale  1 , Manuel Oliveira  1
Affiliations

Prognostic impact of thrombocytosis in gastric cancer-A retrospective study

Bárbara Neto Castro et al. Porto Biomed J. .

Abstract

Background: Solid tumors are a common cause of secondary thrombocytosis, which has been identified as a prognostic factor in various cancers. However, the impact of thrombocytosis on the prognosis of gastric cancer is not yet well defined. The aim of this study was to assess the prevalence and prognostic value of thrombocytosis in patients with gastric cancer.

Methods: This was a retrospective study of patients with gastric carcinoma treated surgically, with curative intent, in our hospital, Centro Hospitalar Vila Nova de Gaia/Espinho, between January 2009 and December 2019. Clinical files were consulted and clinicopathological characteristics were analyzed.

Results: In the present sample (n = 352), the prevalence of pretreatment thrombocytosis was 16.5%. Thrombocytosis was associated with more advanced T stage, greater number of metastatic nodes, and more frequent lymphatic and venous permeation. The presence of thrombocytosis had a negative impact on disease-free survival (hazard ratio [HR] 3.54, 95% confidence interval [CI] 2.35-5.33, P < .001) and overall survival (HR 4.45, 95% CI 2.95-6.71, P < .001).

Conclusions: The presence of pretreatment thrombocytosis had a negative impact on overall survival and disease-free survival and thus could be used as an independent prognostic factor.

Keywords: gastric cancer; thrombocytosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
Impact of thrombocytosis on disease-free survival of patients with gastric cancer.
Figure 2.
Figure 2.
Impact of thrombocytosis on overall survival of patients with gastric cancer.
See this image and copyright information in PMC

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