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. 2024 Feb 14:15:1366852.
doi: 10.3389/fphar.2024.1366852. eCollection 2024.

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Siyang Cao #  1   2   3 , Yihao Wei #  1   2   3 , Yaohang Yue #  1   2   3 , Yingqi Chen  1   2   3 , Shuai Liao  1   2   3 , Aikang Li  1   2   3 , Peng Liu #  1   2   3 , Ao Xiong  1   2   3 , Hui Zeng #  1   2   4
Affiliations

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study

Siyang Cao et al. Front Pharmacol. .

Abstract

In the past 11 years, there has been a surge in studies exploring the regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, a significant gap persists in comprehensive scientometric analysis and scientific mapping research, especially in tracking the evolution, primary contributors, and emerging research focal points. This study aims to comprehensively update the advancements in targeting ferroptosis with various TCMs during the previous 11 years. The data, covering the period from 1 January 2012, to 30 November 2023, were retrieved from the Web of Science database. For in-depth scientometric and visualized analyses, a series of advanced analytical instruments were employed. The findings highlight China's predominant role, accounting for 71.99% of total publications and significantly shaping research in this domain. Noteworthy productivity was observed at various institutions, including Guangzhou University of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, and Zhejiang University. Thomas Efferth emerged as the foremost author within this field, while Frontiers in Pharmacology boasted the highest publication count. This study pinpointed hepatocellular carcinoma, chemical and drug-induced liver injury, mitochondrial diseases, acute kidney injury, and liver failure as the most critical disorders addressed in this research realm. The research offers a comprehensive bibliometric evaluation, enhancing our understanding of the present status of TCM therapy in managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers and newcomers by accelerating access to vital information and fostering innovative concept extraction within this specialized field.

Keywords: Traditional Chinese Medicine; bibliometrics; ferroptosis; global scientific frontiers; visualized analysis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Schematic representation of the literature search and selection process. (B) Trend analysis of research on “ferroptosis-traditional Chinese medicine” from 2012 to 2023.
FIGURE 2
FIGURE 2
(A) Global distribution of “ferroptosis-traditional Chinese medicine (TCM)" research. (B) Chord diagrams illustrating international collaborations. (C) Research output on “Ferroptosis-TCM” from the top 10 countries (highlighted in red signifying increases in document production).
FIGURE 3
FIGURE 3
(A) Diagram illustrating the intensity of institutional cooperation. (B) Top 10 Institutions with Citation Bursts (Red Bars Represent Periods of Increased Citations).
FIGURE 4
FIGURE 4
(A) Author Co-occurrence map. (B) Author cluster analysis. (C) Top 10 authors with significant citation bursts in “ferroptosis-traditional Chinese medicine” publications.
FIGURE 5
FIGURE 5
(A) Density visualization map of Journal citations. (B) Top 20 journals with significant citation bursts. (C) Dual-map overlay of journals in “ferroptosis-traditional Chinese medicine” research.
FIGURE 6
FIGURE 6
(A) Co-citation analysis chart for “ferroptosis-traditional Chinese medicine”. (B) Co-cited literature network map. (C) Top 20 references with the highest citation bursts.
FIGURE 7
FIGURE 7
(A) Keywords intensity visualization timing overlay. (B) Top 10 keywords with significant citation bursts. (C) Co-occurrence analysis chart of Keyword frequencies. (D) temporal trends in Keyword Co-occurrence.
FIGURE 8
FIGURE 8
(A) VOSviewer critical gene clustering visualization. (B) Bubble Plots of gene Ontology enrichment analysis. (C) Kyoto Encyclopedia of genes and Genomes pathway enrichment analysis.
FIGURE 9
FIGURE 9
Ferroptosis plays significant roles in various systemic disorders, including conditions affecting the nervous system, cardiovascular diseases, hepatic disorders, gastrointestinal ailments, respiratory illnesses, renal conditions, pancreatic maladies, and others. This figure was created using Figdraw (https://www.figdraw.com/static/index.html#/). Abbreviations: AKI, acute kidney injury; I/R Injury, ischemia/reperfusion injury.
FIGURE 10
FIGURE 10
(A) Density visualization map of related diseases. (B) Disease clustering analysis chart.
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